hint2 histidine triad nucleotide binding protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hint2provided by ZNC
Official Full Name: histidine triad nucleotide binding protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-139
See related: Ensembl:ENSDARG00000100938 AllianceGenome:ZFIN:ZDB-GENE-070410-139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:163082; si:dkey-87i10.2
Summary: Predicted to enable hydrolase activity. Predicted to be active in mitochondrion. Is expressed in brain; head; inner ear; and somite. Orthologous to human HINT2 (histidine triad nucleotide binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (53009119..53067934)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (52362513..52421341)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins.
Title: Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histidine triad nucleotide-binding protein 2, mitochondrial

Names: histidine triad nucleotide-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083572.2 → NP_001077041.1 histidine triad nucleotide-binding protein 2, mitochondrial

See identical proteins and their annotated locations for NP_001077041.1

Status: PROVISIONAL

Source sequence(s)

BC134222

UniProtKB/TrEMBL

A3KP93, B5TXD7

Related

ENSDARP00000136841.1, ENSDART00000157836.2

Conserved Domains (1) summary

cd01276
Location:51 → 153

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...