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    wnk1b WNK lysine deficient protein kinase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 561159, updated on 4-Jan-2025

    Summary

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    Official Symbol
    wnk1bprovided by ZNC
    Official Full Name
    WNK lysine deficient protein kinase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2656
    See related
    Ensembl:ENSDARG00000039392 AllianceGenome:ZFIN:ZDB-GENE-030131-2656
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wnk1; fc14f06; wu:fc14f06; si:ch211-240l19.1
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within angiogenesis and posterior lateral line neuromast development. Is expressed in several structures, including midbrain neural keel; midbrain neural rod; notochord; posterior lateral line neuromast; and trunk. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See wnk1b in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (8045564..8213152, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (8036938..8198483, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:ch211-240l19.6 Neighboring gene si:ch211-240l19.5 Neighboring gene ninjurin 2 Neighboring gene ELKS/RAB6-interacting/CAST family member 1b Neighboring gene wingless-type MMTV integration site family, member 5b Neighboring gene F-box and leucine-rich repeat protein 14b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio). Bercier V, et al. PLoS Genet, 2013. PMID 23300475, Free PMC Article
    2. WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Sie ZL, et al. Cancers (Basel), 2020 Mar 2. PMID 32131390, Free PMC Article
    3. Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy. Gonzaga-Jauregui C, et al. Cell Rep, 2015 Aug 18. PMID 26257172, Free PMC Article
    4. Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. Lai JG, et al. PLoS One, 2014. PMID 25171174, Free PMC Article
    5. An in silico mining for simple sequence repeats from expressed sequence tags of zebrafish, medaka, Fundulus, and Xiphophorus. Ju Z, et al. In Silico Biol, 2005. PMID 16268789

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. wnk1 is a downstream target for Vegfr2 (vascular endothelial growth factor receptor-2) and Akt/PI3K signaling and thereby affects angiogenesis in zebrafish embryos.
      Title: Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.
    2. loss-of-function mutation in WNK1 induces an overexpression of KCC2 and hinders proper peripheral sensory nerve development, a hallmark of HSANII
      Title: WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within posterior lateral line neuromast development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within posterior lateral line neuromast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase WNK1
    Names
    WNK lysine deficient protein kinase 1
    XP_005164605.1
    XP_009298358.1
    XP_009298360.1
    XP_009298361.1
    XP_009298362.1
    XP_009298363.1
    XP_009298364.1
    XP_009298366.1
    XP_009298367.1
    XP_009298368.1
    XP_009298369.1
    XP_017210742.2
    XP_021327176.1
    XP_021327177.1
    XP_021327178.1
    XP_021327179.1
    XP_021327180.1
    XP_021327181.1
    XP_021327182.1
    XP_021327183.1
    XP_021327185.1
    XP_021327186.1
    XP_021327187.1
    XP_021327188.1
    XP_021327189.1
    XP_021327190.1
    XP_021330879.1
    XP_021330880.1
    XP_021330881.1
    XP_021330882.1
    XP_068074266.1
    XP_068074267.1
    XP_068076836.1
    XP_068076837.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      8045564..8213152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068220735.1 → XP_068076836.1  serine/threonine-protein kinase WNK1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B1I2, A0A8M9PQN2

    2. XM_021475207.2 → XP_021330882.1  serine/threonine-protein kinase WNK1 isoform X15

      UniProtKB/TrEMBL
      A0A8M9PHQ7, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1003 → 1490
      Atrophin-1; Atrophin-1 family

    3. XM_009300094.4 → XP_009298369.1  serine/threonine-protein kinase WNK1 isoform X14

      UniProtKB/TrEMBL
      A0A8M3ARF9, A0A8M9PQN2
      Related
      ENSDARP00000121844.3, ENSDART00000134887.4
      Conserved Domains (4) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam04812
      Location:1109 → 1310
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    4. XM_009300087.4 → XP_009298362.1  serine/threonine-protein kinase WNK1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B8S4, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    5. XM_009300093.4 → XP_009298368.1  serine/threonine-protein kinase WNK1 isoform X11

      UniProtKB/TrEMBL
      A0A8M3B8S9, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    6. XM_009300092.4 → XP_009298367.1  serine/threonine-protein kinase WNK1 isoform X10

      UniProtKB/TrEMBL
      A0A8M3AR72, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    7. XM_009300085.4 → XP_009298360.1  serine/threonine-protein kinase WNK1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AYJ7, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    8. XM_005164548.5 → XP_005164605.1  serine/threonine-protein kinase WNK1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BBS9, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    9. XM_009300089.4 → XP_009298364.1  serine/threonine-protein kinase WNK1 isoform X8

      UniProtKB/TrEMBL
      A0A8M3B1I6, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    10. XM_009300091.4 → XP_009298366.1  serine/threonine-protein kinase WNK1 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AYK0, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    11. XM_009300088.4 → XP_009298363.1  serine/threonine-protein kinase WNK1 isoform X7

      UniProtKB/TrEMBL
      A0A8M3ARF5, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    12. XM_009300086.4 → XP_009298361.1  serine/threonine-protein kinase WNK1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AR69, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    13. XM_021475204.2 → XP_021330879.1  serine/threonine-protein kinase WNK1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9Q0Y6
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    14. XM_009300083.4 → XP_009298358.1  serine/threonine-protein kinase WNK1 isoform X1

      See identical proteins and their annotated locations for XP_009298358.1

      UniProtKB/TrEMBL
      A0A8M3B1I2, A0A8M9PQN2
      Conserved Domains (3) summary
      smart00220
      Location:219 → 472
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    15. XM_068220736.1 → XP_068076837.1  serine/threonine-protein kinase WNK1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B1I2, A0A8M9PQN2

    16. XM_021475206.2 → XP_021330881.1  serine/threonine-protein kinase WNK1 isoform X13

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9Q681
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    17. XM_021475205.2 → XP_021330880.1  serine/threonine-protein kinase WNK1 isoform X12

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9QBQ4
      Related
      ENSDARP00000007995.9, ENSDART00000012928.10
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394549.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      143971..310977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218165.1 → XP_068074266.1  serine/threonine-protein kinase WNK1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9PXY8

    2. XM_021471515.2 → XP_021327190.1  serine/threonine-protein kinase WNK1 isoform X15

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9Q1C0
      Conserved Domains (4) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl25496
      Location:685 → 886
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl26464
      Location:1003 → 1490
      Atrophin-1; Atrophin-1 family

    3. XM_021471514.2 → XP_021327189.1  serine/threonine-protein kinase WNK1 isoform X14

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9PQN8
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1015 → 1502
      Atrophin-1; Atrophin-1 family

    4. XM_021471505.2 → XP_021327180.1  serine/threonine-protein kinase WNK1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9Q1A9
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1431 → 1918
      Atrophin-1; Atrophin-1 family

    5. XM_021471512.2 → XP_021327187.1  serine/threonine-protein kinase WNK1 isoform X11

      UniProtKB/TrEMBL
      A0A8M9P8M8, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1367 → 1854
      Atrophin-1; Atrophin-1 family

    6. XM_021471511.2 → XP_021327186.1  serine/threonine-protein kinase WNK1 isoform X10

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9PY00
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1368 → 1855
      Atrophin-1; Atrophin-1 family

    7. XM_021471502.2 → XP_021327177.1  serine/threonine-protein kinase WNK1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P8L7, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1442 → 1929
      Atrophin-1; Atrophin-1 family

    8. XM_021471503.2 → XP_021327178.1  serine/threonine-protein kinase WNK1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PJN1, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1489 → 1924
      Atrophin-1; Atrophin-1 family

    9. XM_021471508.2 → XP_021327183.1  serine/threonine-protein kinase WNK1 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PJN9, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1495 → 1903
      Atrophin-1; Atrophin-1 family

    10. XM_021471510.2 → XP_021327185.1  serine/threonine-protein kinase WNK1 isoform X9

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9Q1B5
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    11. XM_021471507.2 → XP_021327182.1  serine/threonine-protein kinase WNK1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9P8M2, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    12. XM_021471504.2 → XP_021327179.1  serine/threonine-protein kinase WNK1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PQM6, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    13. XM_021471513.2 → XP_021327188.1  serine/threonine-protein kinase WNK1 isoform X13

      UniProtKB/TrEMBL
      A0A8M9PJP3, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    14. XM_021471506.2 → XP_021327181.1  serine/threonine-protein kinase WNK1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9PXZ3
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    15. XM_021471501.2 → XP_021327176.1  serine/threonine-protein kinase WNK1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9PXY8
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    16. XM_017355253.3 → XP_017210742.2  serine/threonine-protein kinase WNK1 isoform X12

      UniProtKB/TrEMBL
      A0A8M6YY71, A0A8M9PQN2
      Conserved Domains (3) summary
      cd14030
      Location:188 → 476
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:493 → 530
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
      cl26464
      Location:1443 → 1930
      Atrophin-1; Atrophin-1 family

    17. XM_068218166.1 → XP_068074267.1  serine/threonine-protein kinase WNK1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQN2, A0A8M9PXY8
    Nucleotide Protein Strain
    Heading Accession and Version

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