med24 mediator complex subunit 24 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: med24provided by ZNC
Official Full Name: mediator complex subunit 24provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2341
See related: Ensembl:ENSDARG00000099431 AllianceGenome:ZFIN:ZDB-GENE-030131-2341
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: thrap4; fc05c04; trap100; wu:fc05c04
Summary: Predicted to enable transcription coregulator activity. Acts upstream of or within interstitial cell of Cajal differentiation; nervous system development; and thymus development. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in brain; gut; and head. Used to study Hirschsprung's disease; intestinal disease; and neuropathy. Orthologous to human MED24 (mediator complex subunit 24). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (10643692..10674904, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (10605106..10636610, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study revealed a number of defects in the development of the enteric nervous system, interstitial cells of Cajal , and intestinal motility in the zebrafish mutant, lsn
Title: The zebrafish mutant lessen: an experimental model for congenital enteric neuropathies.
Data demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of enteric nervous system precursors in the intestine.
Title: lessen encodes a zebrafish trap100 required for enteric nervous system development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interstitial cell of Cajal differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription initiation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinal cone cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 24

Names: 100 kDa thyroid hormone receptor associated protein; crsp100; crsp4; lessen; lsn; protein lessen; thyroid hormone receptor associated protein 4; thyroid hormone receptor-associated protein 4 homolog; trap100 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039062.1 → NP_001034151.1 mediator of RNA polymerase II transcription subunit 24

See identical proteins and their annotated locations for NP_001034151.1

Status: PROVISIONAL

Source sequence(s)

DQ300265

UniProtKB/Swiss-Prot

Q2PW47

Related

ENSDARP00000132097.1, ENSDART00000157919.3

Conserved Domains (1) summary

pfam11277
Location:1 → 987

Med24_N; Mediator complex subunit 24 N-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

10643692..10674904 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306486.4 → XP_009304761.1 mediator of RNA polymerase II transcription subunit 24 isoform X1

See identical proteins and their annotated locations for XP_009304761.1

UniProtKB/Swiss-Prot

Q2PW47, Q6NUW0

Conserved Domains (1) summary

pfam11277
Location:1 → 987

Med24_N; Mediator complex subunit 24 N-terminal