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    usp20 ubiquitin specific peptidase 20 [ Danio rerio (zebrafish) ]

    Gene ID: 393962, updated on 9-Dec-2024

    Summary

    Official Symbol
    usp20provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 20provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1219
    See related
    Ensembl:ENSDARG00000027501 AllianceGenome:ZFIN:ZDB-GENE-040426-1219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63661; im:7151955
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Predicted to be located in centrosome. Is expressed in central nervous system and yolk syncytial layer. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See usp20 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (33298700..33330479)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (32698528..32730326)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:103692 Neighboring gene mediator complex subunit 22 Neighboring gene prostaglandin E synthase Neighboring gene GTPase activating Rap/RanGAP domain like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC63661

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type peptidase activity  
    enables hydrolase activity  
    enables metal ion binding  
    enables peptidase activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system morphogenesis PubMed 
    acts_upstream_of_or_within cranial skeletal system development PubMed 
    acts_upstream_of_or_within endocytosis  
    involved_in nervous system development  
    involved_in protein K48-linked deubiquitination  
    involved_in protein K63-linked deubiquitination  
    acts_upstream_of_or_within protein deubiquitination  
    involved_in protein deubiquitination  
    acts_upstream_of_or_within proteolysis  
    involved_in regulation of G protein-coupled receptor signaling pathway  
    involved_in regulation of G protein-coupled receptor signaling pathway  
    Component Evidence Code Pubs
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 20
    Names
    deubiquitinating enzyme 20
    ubiquitin specific protease 20
    ubiquitin thioesterase 20
    ubiquitin thiolesterase 20
    ubiquitin-specific-processing protease 20
    NP_957281.2
    XP_009299732.1
    XP_009299733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200987.2 → NP_957281.2  ubiquitin carboxyl-terminal hydrolase 20

      See identical proteins and their annotated locations for NP_957281.2

      Status: PROVISIONAL

      Source sequence(s)
      CR382323
      UniProtKB/Swiss-Prot
      A5PN09
      Conserved Domains (5) summary
      smart00695
      Location:812 → 896
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:443 → 683
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:147 → 252
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:147 → 682
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      33298700..33330479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301458.4 → XP_009299733.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X2

      See identical proteins and their annotated locations for XP_009299733.1

      UniProtKB/Swiss-Prot
      A5PM59, A5PN09
      Related
      ENSDARP00000014964.8, ENSDART00000006021.9
      Conserved Domains (5) summary
      smart00695
      Location:810 → 894
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:443 → 683
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:147 → 252
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:147 → 682
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. XM_009301457.3 → XP_009299732.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B2G6
      Conserved Domains (5) summary
      smart00695
      Location:843 → 927
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:476 → 716
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:180 → 285
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:180 → 715
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:63 → 123
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394588.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      8749..33231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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