rgs14a regulator of G protein signaling 14a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgs14aprovided by ZNC
Official Full Name: regulator of G protein signaling 14aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5579
See related: Ensembl:ENSDARG00000021521 AllianceGenome:ZFIN:ZDB-GENE-030131-5579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rgs14; wu:fi04g12
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within germ cell migration. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in blastomere; epidermis; neural crest; and primordial germ cell. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (871739..899155, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (853475..880891, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The regulator of G-protein signaling 14a protein, regulates the temporal relations between the appearance of the guidance molecules and the acquisition of cellular motility by regulating E-cadherin levels.
Title: Temporal control over the initiation of cell motility by a regulator of G-protein signaling.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fi04g12.x1 (e-PCR)
- UniSTS:196658

G41727 (e-PCR)
- UniSTS:17617

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: regulator of G-protein signaling 14a

Names: regulator of G-protein signalling 14

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201304.1 → NP_958461.1 regulator of G-protein signaling 14a

See identical proteins and their annotated locations for NP_958461.1

Status: PROVISIONAL

Source sequence(s)

BC055659

UniProtKB/TrEMBL

A0A8M3B8C4, Q7SXC7

Related

ENSDARP00000033675.5, ENSDART00000031992.7

Conserved Domains (4) summary

cd01817
Location:321 → 393

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08706
Location:87 → 201

RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins

pfam02188
Location:486 → 507

GoLoco; GoLoco motif

cl00155
Location:401 → 461

UBQ; Ubiquitin-like proteins