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    ndufa8 NADH:ubiquinone oxidoreductase subunit A8 [ Danio rerio (zebrafish) ]

    Gene ID: 393700, updated on 9-Dec-2024

    Summary

    Official Symbol
    ndufa8provided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1688
    See related
    Ensembl:ENSDARG00000058041 AllianceGenome:ZFIN:ZDB-GENE-040426-1688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73139
    Summary
    Predicted to act upstream of or within mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; liver; optic tectum; optic vesicle; and retina. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ndufa8 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (9410337..9419994)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (9576778..9586435)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440063 Neighboring gene LIM homeobox 6a Neighboring gene MORN repeat containing 5 Neighboring gene uncharacterized LOC137496562 Neighboring gene uncharacterized LOC137496563

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC73139

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
    NP_957021.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200727.1NP_957021.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

      See identical proteins and their annotated locations for NP_957021.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059501
      UniProtKB/TrEMBL
      A0A8M1PDB8, Q6PC22
      Related
      ENSDARP00000075289.4, ENSDART00000080843.5
      Conserved Domains (1) summary
      pfam06747
      Location:78111
      CHCH; CHCH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      9410337..9419994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394770.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      209529..217626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)