foxo3a forkhead box O3A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: foxo3aprovided by ZNC
Official Full Name: forkhead box O3Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050116-1
See related: Ensembl:ENSDARG00000023058 AllianceGenome:ZFIN:ZDB-GENE-050116-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb50g02; fi33f07; zgc:92176; wu:fb50g02; wu:fi33f07
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of nervous system development and regulation of neuron apoptotic process. Predicted to be active in nucleus. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including brain; digestive system; eye; pericardial region; and pleuroperitoneal region. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (6793001..6810785)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (6635771..6653555)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
Title: Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL).
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
Title: Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish.

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General gene information

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Markers

AI477224 (e-PCR)
- UniSTS:206507

fi33f07.x1 (e-PCR)
- UniSTS:197319

AW175226 (e-PCR)
- UniSTS:205781

fb50g02.x1 (e-PCR)
- UniSTS:203255

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
colocalizes_with mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein O3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009988.1 → NP_001009988.1 forkhead box protein O3a

See identical proteins and their annotated locations for NP_001009988.1

Status: PROVISIONAL

Source sequence(s)

BC088386

UniProtKB/TrEMBL

A0A8M1N3S8, Q5I0F7

Related

ENSDARP00000036177.4, ENSDART00000030773.5

Conserved Domains (3) summary

cd00059
Location:140 → 220

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16675
Location:417 → 492

FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2

pfam16676
Location:576 → 615

FOXO-TAD; Transactivation domain of FOXO protein family