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    snai3 snail family zinc finger 3 [ Danio rerio (zebrafish) ]

    Gene ID: 567724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snai3provided by ZNC
    Official Full Name
    snail family zinc finger 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-757
    See related
    Ensembl:ENSDARG00000031243 AllianceGenome:ZFIN:ZDB-GENE-061013-757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153535
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in notochord and somite. Orthologous to human SNAI3 (snail family transcriptional repressor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snai3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (55112983..55120300)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (54811572..54818889)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene two pore segment channel 2 Neighboring gene glutamine-dependent NAD(+) synthetase-like Neighboring gene uncharacterized LOC108179210 Neighboring gene coiled-coil domain-containing protein 106-like Neighboring gene cadherin 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. snail gene expression in the medaka, Oryzias latipes. Liedtke D, et al. Gene Expr Patterns, 2011 Mar-Apr. PMID 21094700
    2. Amiodarone Induces Overexpression of Similar to Versican b to Repress the EGFR/Gsk3b/Snail Signaling Axis during Cardiac Valve Formation of Zebrafish Embryos. Lee HC, et al. PLoS One, 2015. PMID 26650936, Free PMC Article
    3. Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family. Manzanares M, et al. Dev Genes Evol, 2004 Jan. PMID 14655014
    4. Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. Taylor KM, et al. Biochem J, 2016 Aug 15. PMID 27274087, Free PMC Article
    5. Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. Bickers C, et al. PLoS One, 2018. PMID 30208064, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
      Title: Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC153535

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein SNAI3
    Names
    snail homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077385.2 → NP_001070853.1  zinc finger protein SNAI3

      See identical proteins and their annotated locations for NP_001070853.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124692
      UniProtKB/TrEMBL
      Q08BJ5
      Related
      ENSDARP00000068039.5, ENSDART00000073549.6
      Conserved Domains (3) summary
      sd00017
      Location:202 → 222
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:228 → 250
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:215 → 238
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      55112983..55120300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222357.1 → XP_068078458.1  zinc finger protein SNAI3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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