pth2 parathyroid hormone 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pth2provided by ZNC
Official Full Name: parathyroid hormone 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041102-1
See related: Ensembl:ENSDARG00000022951 AllianceGenome:ZFIN:ZDB-GENE-041102-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tip39
Summary: Enables receptor ligand activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; startle response; and swimming behavior. Predicted to be located in extracellular region. Is expressed in several structures, including central nervous system; eye; immature eye; liver and biliary system; and pericardial region. Orthologous to human PTH2 (parathyroid hormone 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (33495194..33499023)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (33542683..33546512)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The neuropeptide Pth2 dynamically senses others via mechanosensation.
Title: The neuropeptide Pth2 dynamically senses others via mechanosensation.
Data indicate that the expression of pth2 and pth2r mRNA in the ear at the same time suggesting a role in otic development.
Title: Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development.
A single TIP39 gene was identified for zebrafish species, which showed significant homology to mammalian TIP39
Title: Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tuberoinfundibular peptide of 39 residues

Names: hypothalamic neuropeptide; tuberoinfundibular peptide of 39 amino acids

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.