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    cita citron rho-interacting serine/threonine kinase a [ Danio rerio (zebrafish) ]

    Gene ID: 100329792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    citaprovided by ZNC
    Official Full Name
    citron rho-interacting serine/threonine kinase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130530-981
    See related
    Ensembl:ENSDARG00000089856 AllianceGenome:ZFIN:ZDB-GENE-130530-981
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cit
    Summary
    Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cita in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (2409554..2642786, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (2142305..2372592, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene glucuronidase, beta Neighboring gene uncharacterized LOC137495508 Neighboring gene carbonic anhydrase IV a Neighboring gene myotubularin related protein 4 Neighboring gene uncharacterized LOC103910293 Neighboring gene RAB35, member RAS oncogene family a Neighboring gene guanine nucleotide binding protein (G protein), gamma 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
    2. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    citron Rho-interacting kinase; citron rho-interacting kinase
    Names
    zmp:0000000978

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      2409554..2642786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476726.2 → XP_021332401.1  citron rho-interacting kinase isoform X4

      UniProtKB/TrEMBL
      A0A8M9QA07
      Conserved Domains (5) summary
      smart00233
      Location:1503 → 1622
      PH; Pleckstrin homology domain
      cd00029
      Location:1422 → 1470
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02434
      Location:1652 → 1948
      CNH; CNH domain
      cl21453
      Location:96 → 426
      PKc_like; Protein Kinases, catalytic domain
      cl25732
      Location:476 → 1287
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_021476724.2 → XP_021332399.1  citron rho-interacting kinase isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q5W0
      Conserved Domains (5) summary
      smart00233
      Location:1503 → 1622
      PH; Pleckstrin homology domain
      cd00029
      Location:1422 → 1470
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02434
      Location:1666 → 1962
      CNH; CNH domain
      cl21453
      Location:96 → 426
      PKc_like; Protein Kinases, catalytic domain
      cl25732
      Location:476 → 1287
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_021476725.2 → XP_021332400.1  citron rho-interacting kinase isoform X3

      UniProtKB/TrEMBL
      A0A8M9QF24
      Related
      ENSDARP00000108825.2, ENSDART00000122274.3
      Conserved Domains (5) summary
      smart00233
      Location:1511 → 1630
      PH; Pleckstrin homology domain
      cd00029
      Location:1430 → 1478
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02434
      Location:1660 → 1956
      CNH; CNH domain
      cl21453
      Location:96 → 426
      PKc_like; Protein Kinases, catalytic domain
      cl25732
      Location:476 → 1287
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_021476723.2 → XP_021332398.1  citron rho-interacting kinase isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZB2
      Conserved Domains (5) summary
      smart00233
      Location:1511 → 1630
      PH; Pleckstrin homology domain
      cd00029
      Location:1430 → 1478
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02434
      Location:1674 → 1970
      CNH; CNH domain
      cl21453
      Location:96 → 426
      PKc_like; Protein Kinases, catalytic domain
      cl25732
      Location:476 → 1287
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_068221349.1 → XP_068077450.1  citron Rho-interacting kinase isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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