fh fumarate hydratase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fhprovided by ZNC
Official Full Name: fumarate hydrataseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010724-6
See related: Ensembl:ENSDARG00000075132 AllianceGenome:ZFIN:ZDB-GENE-010724-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Fh1; zf-e152; zgc:66253; zgc:77498; im:7152785; ns:zf-e152
Summary: Predicted to enable fumarate hydratase activity. Predicted to be involved in several processes, including dicarboxylic acid metabolic process; positive regulation of double-strand break repair via nonhomologous end joining; and tricarboxylic acid cycle. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; liver; and optic tectum. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (47638430..47648538, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (47640572..47650680, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of zebrafish fumarate hydratase active site by molecular docking and simulation studies.
Title: Identification of zebrafish fumarate hydratase active site by molecular docking and simulation studies.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fumarate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fumarate hydratase activity	IEA Inferred from Electronic Annotation more info
enables fumarate hydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in fumarate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fumarate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fumarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in malate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of arginine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of urea cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tricarboxylic acid cycle heteromeric enzyme complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fumarate hydratase, mitochondrial

Names: fumarase

NP_957257.1

EC 4.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.