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    cadm4 cell adhesion molecule 4 [ Danio rerio (zebrafish) ]

    Gene ID: 492787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cadm4provided by ZNC
    Official Full Name
    cell adhesion molecule 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-138
    See related
    Ensembl:ENSDARG00000040291 AllianceGenome:ZFIN:ZDB-GENE-041114-138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101704
    Summary
    Predicted to enable vascular endothelial growth factor receptor 2 binding activity. Acts upstream of or within bulbus arteriosus formation; glial cell development; and retina development in camera-type eye. Predicted to be located in plasma membrane. Predicted to be active in cell-cell contact zone. Is expressed in basal plate midbrain region; immature eye; nervous system; and presumptive bulbus arteriosus. Orthologous to human CADM4 (cell adhesion molecule 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cadm4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (24213078..24518054, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (24298046..24603032, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene basal cell adhesion molecule (Lutheran blood group) Neighboring gene ribosomal protein S19 Neighboring gene si:ch211-79k12.3 Neighboring gene si:ch211-79k12.1 Neighboring gene si:ch211-79k12.2 Neighboring gene NF-kappa-B inhibitor delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system. Hunter PR, et al. J Comp Neurol, 2011 Aug 1. PMID 21456004
    2. Six cadm/SynCAM genes are expressed in the nervous system of developing zebrafish. Pietri T, et al. Dev Dyn, 2008 Jan. PMID 18095341, Free PMC Article
    3. The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Baek S, et al. Dev Cell, 2019 Apr 22. PMID 31014480
    4. Cadm4 restricts the production of cardiac outflow tract progenitor cells. Zeng XX, et al. Cell Rep, 2014 May 22. PMID 24813897, Free PMC Article
    5. Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Wang D, et al. J Hazard Mater, 2021 Jul 5. PMID 33621777

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bulbus arteriosus formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell adhesion molecule 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007428.2 → NP_001007429.2  cell adhesion molecule 4 precursor

      Status: VALIDATED

      Source sequence(s)
      CR391920, CR854851, CT867948, CT867949
      UniProtKB/TrEMBL
      Q5U3R8
      Related
      ENSDARP00000114285.1, ENSDART00000143761.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      24213078..24518054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158112.3 → XP_005158169.1  cell adhesion molecule 4 isoform X2

      See identical proteins and their annotated locations for XP_005158169.1

      UniProtKB/TrEMBL
      A0A8M2B512, B0CLV3, Q5U3R8
      Related
      ENSDARP00000113242.1, ENSDART00000134120.3
      Conserved Domains (4) summary
      smart00294
      Location:370 → 387
      4.1m; putative band 4.1 homologues' binding motif
      smart00410
      Location:233 → 311
      IG_like; Immunoglobulin like
      pfam13895
      Location:230 → 298
      Ig_2; Immunoglobulin domain
      cl11960
      Location:144 → 223
      Ig; Immunoglobulin domain

    2. XM_068213952.1 → XP_068070053.1  cell adhesion molecule 4 isoform X3

      UniProtKB/TrEMBL
      Q5U3R8

    3. XM_005158111.5 → XP_005158168.1  cell adhesion molecule 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B4F3, A0A8M2B4X9
      Conserved Domains (4) summary
      smart00294
      Location:372 → 389
      4.1m; putative band 4.1 homologues' binding motif
      smart00410
      Location:235 → 313
      IG_like; Immunoglobulin like
      pfam13895
      Location:232 → 300
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146 → 225
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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