pex5 peroxisomal biogenesis factor 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pex5provided by ZNC
Official Full Name: peroxisomal biogenesis factor 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-981
See related: Ensembl:ENSDARG00000070654 AllianceGenome:ZFIN:ZDB-GENE-040426-981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PXR1; zgc:56318
Summary: Predicted to enable peroxisome matrix targeting signal-1 binding activity. Predicted to be involved in protein import into peroxisome matrix, docking. Predicted to act upstream of or within protein transport. Predicted to be located in peroxisomal matrix. Predicted to be active in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to human PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (12064575..12097395, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (12173673..12206560, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS.
Title: PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS.
Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy.
Title: Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxisomal biogenesis factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201156.1 → NP_957450.1 peroxisomal biogenesis factor 5

See identical proteins and their annotated locations for NP_957450.1

Status: PROVISIONAL

Source sequence(s)

BC046070

UniProtKB/TrEMBL

A0A8M3AHU4, Q7ZUZ1

Related

ENSDARP00000094720.3, ENSDART00000103944.5

Conserved Domains (3) summary

sd00006
Location:436 → 464

TPR; TPR repeat [structural motif]

pfam00515
Location:473 → 503

TPR_1; Tetratricopeptide repeat

pfam13414
Location:435 → 501

TPR_11; TPR repeat