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    nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL [ Danio rerio (zebrafish) ]

    Gene ID: 550369, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nsdhlprovided by ZNC
    Official Full Name
    NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHLprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-163
    See related
    Ensembl:ENSDARG00000099315 AllianceGenome:ZFIN:ZDB-GENE-050417-163
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112474
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Acts upstream of or within response to yeast. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent steroid dehydrogenase-like). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See nsdhl in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (14646717..14659083, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (14341154..14353520, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene RAB9B, member RAS oncogene family Neighboring gene fucosyltransferase 11 (alpha (1,3) fucosyltransferase) Neighboring gene zinc finger protein 185 with LIM domain Neighboring gene centrin, EF-hand protein, 2 Neighboring gene germ cell nuclear acidic peptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regeneration Rosetta: An Interactive Web Application To Explore Regeneration-Associated Gene Expression and Chromatin Accessibility. Rau A, et al. G3 (Bethesda), 2019 Dec 3. PMID 31575636, Free PMC Article
    2. Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Weger M, et al. J Neuroendocrinol, 2018 Apr. PMID 29486070
    3. Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Li RF, et al. Biomedicines, 2022 May 27. PMID 35740282, Free PMC Article
    4. MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. Weger M, et al. Elife, 2020 Sep 24. PMID 32969791, Free PMC Article
    5. Functional characterization of stap2b in zebrafish vascular development. Wang YS, et al. FASEB J, 2023 Jul. PMID 37342918

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to yeast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
    Names
    NAD(P) dependent steroid dehydrogenase-like
    NP_001017674.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017674.1 → NP_001017674.1  sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

      See identical proteins and their annotated locations for NP_001017674.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093332
      UniProtKB/TrEMBL
      Q566U2
      Related
      ENSDARP00000140493.1, ENSDART00000172241.2
      Conserved Domains (2) summary
      pfam01073
      Location:14 → 260
      3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
      cl21454
      Location:11 → 338
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      14646717..14659083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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