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    rcan2 regulator of calcineurin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 407988, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rcan2provided by ZNC
    Official Full Name
    regulator of calcineurin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040516-17
    See related
    Ensembl:ENSDARG00000021869 AllianceGenome:ZFIN:ZDB-GENE-040516-17
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    DSCR1L1; zgc:85746; si:ch211-124g24.1
    Summary
    Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in calcium-mediated signaling. Predicted to be active in cytoplasm and nucleus. Orthologous to human RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rcan2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (39053461..39188476, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (39150582..39285597, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488676 Neighboring gene methionine sulfoxide reductase Aa Neighboring gene uncharacterized LOC108180313 Neighboring gene cytochrome P450, family 39, subfamily A, polypeptide 1 Neighboring gene RALBP1 associated Eps domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control. Stevenson NL, et al. J Cell Sci, 2018 May 4. PMID 29643119, Free PMC Article
    2. The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. Jiang X, et al. PLoS Biol, 2024 Mar. PMID 38527087, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b.
      Title: The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcipressin-2
    Names
    Down syndrome critical region gene 1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320228.1 → NP_001307157.1  calcipressin-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL929058, BX569784, CR383663
      UniProtKB/TrEMBL
      A0A8M1P7L9, E7F2L5
      Related
      ENSDARP00000127405.1, ENSDART00000152858.2
      Conserved Domains (1) summary
      pfam04847
      Location:65 → 232
      Calcipressin; Calcipressin

    2. NM_214819.2 → NP_999984.1  calcipressin-2 isoform 2

      See identical proteins and their annotated locations for NP_999984.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BX569784, CR383663
      UniProtKB/TrEMBL
      A0A8M1PHP2, Q6NSN4
      Related
      ENSDARP00000114023.1, ENSDART00000143379.3
      Conserved Domains (1) summary
      pfam04847
      Location:22 → 189
      Calcipressin; Calcipressin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      39053461..39188476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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