glra4b glycine receptor, alpha 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glra4bprovided by ZNC
Official Full Name: glycine receptor, alpha 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020402-2
See related: Ensembl:ENSDARG00000058103 AllianceGenome:ZFIN:ZDB-GENE-020402-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: glyRalpha4
Summary: Enables extracellularly glycine-gated ion channel activity. Acts upstream of or within excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in cell projection and membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; hindbrain; retinal ganglion cell layer; retinal inner nuclear layer; and spinal cord. Orthologous to human GLRA4 (glycine receptor alpha 4 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (22515352..22544138, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (22011552..22040338, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycine receptor, alpha 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202511.1 → NP_001189440.1 glycine receptor, alpha 4b precursor

Status: PROVISIONAL

Source sequence(s)

BC085599

UniProtKB/TrEMBL

A0A8M1P2L1, Q5U3C8

Related

ENSDARP00000026925.9, ENSDART00000006474.10

Conserved Domains (3) summary

TIGR00860
Location:5 → 478

LIC; Cation transporter family protein

pfam02931
Location:47 → 253

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:260 → 475

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region