gon4lb gon-4 like b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gon4lbprovided by ZNC
Official Full Name: gon-4 like bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070117-2447
See related: Ensembl:ENSDARG00000005867 AllianceGenome:ZFIN:ZDB-GENE-070117-2447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: udu; gon4l; fb99g07; wu:fb99g07
Summary: Predicted to enable transcription coregulator activity. Acts upstream of or within notochord morphogenesis. Predicted to be active in nucleus. Is expressed in intermediate cell mass of mesoderm; nervous system; notochord; otic vesicle; and pronephros. Orthologous to several human genes including GON4L (gon-4 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (28994709..29024769)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (29060086..29090146)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Newly identified Gon4l/Udu-interacting proteins implicate novel functions.
Title: Newly identified Gon4l/Udu-interacting proteins implicate novel functions.
Gon4l/Udu regulates cardiomyocyte proliferation and maintenance of ventricular chamber identity during zebrafish development.
Title: Gon4l/Udu regulates cardiomyocyte proliferation and maintenance of ventricular chamber identity during zebrafish development.
Gon4l cooperates with planar cell polarity signaling to coordinate morphogenesis along the anterioposterior embryonic axis
Title: Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes.
Data show that Udu is colocalized with 5-bromo-2'-deoxyuridine and heterochromatin during DNA replication, suggesting a role in maintaining genome integrity.
Title: Udu deficiency activates DNA damage checkpoint.
the Udu protein (ugly duckling (Udu) mutant allele) is very likely to function as a transcription modulator essential for the proliferation and differentiation of erythroid lineage.
Title: The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development.

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General gene information

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Markers

fb99g07.x1 (e-PCR)
- UniSTS:203644

fe15g10.y1 (e-PCR)
- UniSTS:196228

fc75f06.y1 (e-PCR)
- UniSTS:194454

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within notochord morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GON-4-like protein

Names: gon-4-like; ugly duckling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201535.1 → NP_001188464.1 GON-4-like protein

Status: VALIDATED

Source sequence(s)

CR848841

UniProtKB/TrEMBL

A0A8M1P2G5, F1QI87

Related

ENSDARP00000082456.3, ENSDART00000088023.4

Conserved Domains (2) summary

cd12202
Location:1969 → 2033

CASP8AP2; Caspase 8-associated protein 2 myb-like domain

pfam02671
Location:1593 → 1638

PAH; Paired amphipathic helix repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

28994709..29024769

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001097583.1: Suppressed sequence

Description

NM_001097583.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from Norway rat: LOC499653 (GeneID:499653).