clic5b chloride intracellular channel 5b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: clic5bprovided by ZNC
Official Full Name: chloride intracellular channel 5bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2542
See related: Ensembl:ENSDARG00000070584 AllianceGenome:ZFIN:ZDB-GENE-040426-2542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: clic5; clic5a; zgc:77538; im:6907594
Summary: Predicted to enable chloride channel activity. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in cytoplasm and membrane. Predicted to be part of chloride channel complex. Is expressed in digestive system; immature eye; pronephric duct; and sensory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to human CLIC5 (chloride intracellular channel 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (43925335..43968320)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (44028257..44071242)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel role for the chloride intracellular channel protein Clic5 in ciliary function.
Title: A novel role for the chloride intracellular channel protein Clic5 in ciliary function.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chloride intracellular channel protein 5b

Names: chloride intracellular channel 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098198.1 → NP_001091668.1 chloride intracellular channel protein 5b isoform 1

See identical proteins and their annotated locations for NP_001091668.1

Status: PROVISIONAL

Source sequence(s)

CR392340

UniProtKB/TrEMBL

A2CEF5, B3DFY7, K7DXY6

Related

ENSDARP00000091344.4, ENSDART00000100571.5

Conserved Domains (3) summary

TIGR00862
Location:7 → 242

O-ClC; intracellular chloride channel protein

cd10297
Location:101 → 241

GST_C_CLIC5; C-terminal, alpha helical domain of Chloride Intracellular Channel 5

cd03061
Location:6 → 94

GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...
NM_212897.1 → NP_998062.1 chloride intracellular channel protein 5b isoform 2

See identical proteins and their annotated locations for NP_998062.1

Status: PROVISIONAL

Source sequence(s)

BC067160

UniProtKB/TrEMBL

Q6NXB5

Related

ENSDARP00000029090.8, ENSDART00000037379.11

Conserved Domains (3) summary

TIGR00862
Location:172 → 407

O-ClC; intracellular chloride channel protein

cd10297
Location:266 → 406

GST_C_CLIC5; C-terminal, alpha helical domain of Chloride Intracellular Channel 5

cd03061
Location:170 → 259

GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...