top1mt DNA topoisomerase I mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: top1mtprovided by ZNC
Official Full Name: DNA topoisomerase I mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040624-2
See related: Ensembl:ENSDARG00000104809 AllianceGenome:ZFIN:ZDB-GENE-040624-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable DNA binding activity and DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA topological change. Predicted to be located in chromosome and nucleus. Orthologous to human TOP1MT (DNA topoisomerase I mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (42004609..42018360)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (42115967..42144945)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi15d03.x1 (e-PCR)
- UniSTS:196871

Z8456 (e-PCR)
- UniSTS:54047

fd10d06.y1 (e-PCR)
- UniSTS:195105

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase activity	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA topological change	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA topological change	IEA Inferred from Electronic Annotation more info
involved_in DNA topological change	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA topoisomerase I, mitochondrial

Names: mitochondrial topoisomerase I; topoisomerase (DNA) I, mitochondrial

NP_001001838.1

EC 5.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001838.1 → NP_001001838.1 DNA topoisomerase I, mitochondrial precursor

See identical proteins and their annotated locations for NP_001001838.1

Status: PROVISIONAL

Source sequence(s)

AY429655

UniProtKB/TrEMBL

Q6T721

Related

ENSDARP00000131182.2, ENSDART00000171380.2

Conserved Domains (5) summary

smart00435
Location:196 → 571

TOPEUc; DNA Topoisomerase I (eukaryota)

cd03488
Location:52 → 266

Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...

pfam01028
Location:268 → 470

Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core

pfam14370
Location:531 → 598

Topo_C_assoc; C-terminal topoisomerase domain

cl09111
Location:477 → 548

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...