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    pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100049158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pkmyt1provided by ZNC
    Official Full Name
    protein kinase, membrane associated tyrosine/threonine 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-80
    See related
    Ensembl:ENSDARG00000074730 AllianceGenome:ZFIN:ZDB-GENE-060810-80
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7157379; zgc:163016
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pkmyt1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (14965587..15002592, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (14927284..14964697, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene neuronal differentiation 2 Neighboring gene uncharacterized LOC137496802 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle b Neighboring gene phenylethanolamine N-methyltransferase Neighboring gene uncharacterized LOC101882309

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
    NP_001091666.1
    XP_005156179.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098196.1 → NP_001091666.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

      See identical proteins and their annotated locations for NP_001091666.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139690
      UniProtKB/TrEMBL
      A4VCH1
      Related
      ENSDARP00000100899.1, ENSDART00000108852.4
      Conserved Domains (2) summary
      smart00220
      Location:108 → 371
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14050
      Location:106 → 369
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      14965587..15002592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156122.5 → XP_005156179.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

      See identical proteins and their annotated locations for XP_005156179.1

      UniProtKB/TrEMBL
      A0A8M2B244, B1H1M4
      Related
      ENSDARP00000122987.1, ENSDART00000141909.2
      Conserved Domains (2) summary
      smart00220
      Location:108 → 371
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14050
      Location:106 → 369
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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