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    plcb2 phospholipase C, beta 2 [ Danio rerio (zebrafish) ]

    Gene ID: 569376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plcb2provided by ZNC
    Official Full Name
    phospholipase C, beta 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080419-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-080419-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable calcium ion binding activity and phosphatidylinositol phospholipase C activity. Acts upstream of or within atrioventricular canal development and determination of heart left/right asymmetry. Is expressed in digestive system; oral cavity; and taste bud. Used to study congenital heart disease. Orthologous to human PLCB2 (phospholipase C beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See plcb2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (2335547..2427807, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (2160719..2251777, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63 Neighboring gene coiled-coil domain containing 9B Neighboring gene uncharacterized LOC137488060

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish. Birdal G, et al. Chem Senses, 2023 Jan 1. PMID 37843175
    2. Transgenic labeling of taste receptor cells in model fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2 gene. Aihara Y, et al. Gene Expr Patterns, 2007 Jan. PMID 16920036
    3. Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease. Izarzugaza JMG, et al. Genome Med, 2020 Aug 28. PMID 32859249, Free PMC Article
    4. Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs. Soulika M, et al. Development, 2016 Jun 1. PMID 27122167
    5. Characterization of ligands for fish taste receptors. Oike H, et al. J Neurosci, 2007 May 23. PMID 17522303, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of taste sentinels, T1R, T2R, and PLCbeta2, on the passageway for olfactory signals in zebrafish.
      Title: Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within atrioventricular canal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    Names
    plcb2l
    zfPLC-beta2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      2335547..2427807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214665.1 → XP_068070766.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

      UniProtKB/TrEMBL
      A0A8M9P9T2
    Nucleotide Protein Strain
    Heading Accession and Version

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