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    fezf2 FEZ family zinc finger 2 [ Danio rerio (zebrafish) ]

    Gene ID: 60634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fezf2provided by ZNC
    Official Full Name
    FEZ family zinc finger 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001103-3
    See related
    Ensembl:ENSDARG00000070677 AllianceGenome:ZFIN:ZDB-GENE-001103-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fez; tof; fezl; cadps; zgc:92690; SI:dZ6A2.1; SI:dZ6A2.7; foreheadin
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Acts upstream of or within several processes, including nervous system development; neuronal stem cell population maintenance; and regulation of Notch signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; neural keel; neural plate; neuroectoderm; and optic vesicle. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fezf2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (20056732..20059410)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (19894390..19897230)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene nicotinamide phosphoribosyltransferase 2 Neighboring gene Ca2+-dependent activator protein for secretion a Neighboring gene si:dkey-274m17.3 Neighboring gene opioid growth factor receptor 2 Neighboring gene uncharacterized LOC108191636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Rink E, et al. Neuroscience, 2004. PMID 15219677
    2. A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression. Yang Z, et al. Dev Biol, 2001 Mar 1. PMID 11180958
    3. Expression of the zinc finger gene fez-like in zebrafish forebrain. Hashimoto H, et al. Mech Dev, 2000 Oct. PMID 11025224
    4. fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Berberoglu MA, et al. Gene Expr Patterns, 2009 Sep. PMID 19524703, Free PMC Article
    5. Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. Chen L, et al. J Biol Chem, 2011 May 27. PMID 21471212, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fezf2 is important for early development of the posterior hypothalamus.
      Title: Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2.
    2. This study demonistrated that Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain.
      Title: Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain.
    3. the feasibility of employing genomic SELEX to identify vertebrate transcription factor binding sites and target genes and reveal Fezf2 as a transcription activator
      Title: Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes.
    4. identify neurogenin 1 as a determinant of brain dopaminergic neurons and provide insights into how Tof/Fezl regulates the development of these clinically important neuronal types
      Title: Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC92690

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within commissural neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within diencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within forebrain neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hypothalamus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammillary body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fez family zinc finger protein 2
    Names
    forebrain embryonic zinc finger-like protein 2
    forebrain embryonic zinc-finger like
    too few
    zinc-finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131636.2 → NP_571711.2  fez family zinc finger protein 2

      Status: VALIDATED

      Source sequence(s)
      BX276115
      UniProtKB/TrEMBL
      A0A8M2B2Q7, G1K2U0
      Related
      ENSDARP00000094772.3, ENSDART00000103997.5
      Conserved Domains (2) summary
      COG5048
      Location:231 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      20056732..20059410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479660.2 → XP_021335335.1  fez family zinc finger protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2Q7, G1K2U0
      Conserved Domains (2) summary
      COG5048
      Location:231 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_005155837.5 → XP_005155894.1  fez family zinc finger protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005155894.1

      UniProtKB/TrEMBL
      A0A8M2B2Q7, G1K2U0
      Conserved Domains (2) summary
      COG5048
      Location:231 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_005155838.5 → XP_005155895.1  fez family zinc finger protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005155895.1

      UniProtKB/TrEMBL
      A0A8M2B2Q7, G1K2U0
      Related
      ENSDARP00000156395.1, ENSDART00000184979.1
      Conserved Domains (2) summary
      COG5048
      Location:231 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q804Q5.2 GenPept UniProtKB/Swiss-Prot:Q804Q5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.