irf7 interferon regulatory factor 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: irf7provided by ZNC
Official Full Name: interferon regulatory factor 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1518
See related: Ensembl:ENSDARG00000045661 AllianceGenome:ZFIN:ZDB-GENE-040426-1518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66043; zgc:77947; wu:fl24c03
Summary: Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including negative regulation of hematopoietic stem cell differentiation; neuromast hair cell development; and response to virus. Located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; digestive system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (25546789..25550944, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (25451711..25455866, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
Title: Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway.
Title: Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway.
Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis.
Title: Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis.
Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
Title: Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
Following spring viremia of carp virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp virus. data provide evidence that fish and mammals have evolved a similar IRF-dependent regulatory mechanism fine-tuning IFN gene activation.
Title: Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes.
Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
Title: Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7.
The miR-142a-3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
Title: miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune system process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of hematopoietic stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon regulatory factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313779.1 → NP_001300708.1 interferon regulatory factor 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in its 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AL928892, EH494710, EH521037

UniProtKB/TrEMBL

A0A8M1P7R4, H0WFC4

Related

ENSDARP00000125556.1, ENSDART00000150412.3

Conserved Domains (2) summary

pfam00605
Location:9 → 108

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:171 → 343

IRF-3; Interferon-regulatory factor 3
NM_200677.2 → NP_956971.2 interferon regulatory factor 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).

Source sequence(s)

AL928892, EH494710, EH521037

UniProtKB/TrEMBL

A0A8M1PFL5, F1QNG2

Related

ENSDARP00000094398.3, ENSDART00000103622.5

Conserved Domains (2) summary

pfam00605
Location:9 → 108

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:216 → 388

IRF-3; Interferon-regulatory factor 3