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    cry5 cryptochrome circadian regulator 5 [ Danio rerio (zebrafish) ]

    Gene ID: 83776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cry5provided by ZNC
    Official Full Name
    cryptochrome circadian regulator 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010426-8
    See related
    Ensembl:ENSDARG00000019498 AllianceGenome:ZFIN:ZDB-GENE-010426-8
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    z64phr; z6-4phr
    Summary
    Enables DNA (6-4) photolyase activity. Acts upstream of or within DNA repair and response to light stimulus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; eye; integument; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cry5 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (39268518..39283812, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (39347031..39362391, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene decapping enzyme, scavenger Neighboring gene potassium inwardly rectifying channel subfamily J member 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Early embryonic light detection improves survival. Tamai TK, et al. Curr Biol, 2004 Feb 3. PMID 14986634
    2. Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Osaki T, et al. Biol Pharm Bull, 2011. PMID 21804230
    3. ERK Signaling Regulates Light-Induced Gene Expression via D-Box Enhancers in a Differential, Wavelength-Dependent Manner. Mracek P, et al. PLoS One, 2013. PMID 23840779, Free PMC Article
    4. Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair. Zhao H, et al. PLoS Genet, 2021 Feb. PMID 33544716, Free PMC Article
    5. Clock genes rescue nphp mutations in zebrafish. Kayser N, et al. Hum Mol Genet, 2022 Dec 16. PMID 35861640, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA (6-4) photolyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribodipyrimidine photo-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to light stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cryptochrome circadian regulator 5
    Names
    6-4 photolyase
    cry5/6-4phr
    cryptochrome 5
    cryptochrome circadian clock 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131788.1 → NP_571863.1  cryptochrome circadian regulator 5

      See identical proteins and their annotated locations for NP_571863.1

      Status: PROVISIONAL

      Source sequence(s)
      AB042254
      UniProtKB/TrEMBL
      Q9I911
      Related
      ENSDARP00000144318.1, ENSDART00000175136.2
      Conserved Domains (3) summary
      COG0415
      Location:5 → 486
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam00875
      Location:5 → 170
      DNA_photolyase; DNA photolyase
      pfam03441
      Location:213 → 485
      FAD_binding_7; FAD binding domain of DNA photolyase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      39268518..39283812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155405.4 → XP_005155462.1  cryptochrome circadian regulator 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B1I7, F1QHM9
      Related
      ENSDARP00000015621.5, ENSDART00000023831.6
      Conserved Domains (3) summary
      COG0415
      Location:5 → 486
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam00875
      Location:5 → 170
      DNA_photolyase; DNA photolyase
      pfam03441
      Location:213 → 485
      FAD_binding_7; FAD binding domain of DNA photolyase
    Nucleotide Protein Strain
    Heading Accession and Version

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