cdt1 chromatin licensing and DNA replication factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdt1provided by ZNC
Official Full Name: chromatin licensing and DNA replication factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-070111-1
See related: Ensembl:ENSDARG00000051854 AllianceGenome:ZFIN:ZDB-GENE-070111-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc37h07; im:7158083; wu:fc37h07; wu:fi38h09
Summary: Predicted to enable DNA binding activity and DNA polymerase binding activity. Acts upstream of or within mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; mesoderm; proliferative region; pronephric duct; and somite. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (55518519..55530662)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (55217099..55229335)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA replication preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_690072.9 → XP_695164.3 DNA replication factor Cdt1 isoform X1

UniProtKB/TrEMBL

A0A8N7T7X4, E7F2R5

Related

ENSDARP00000089247.4, ENSDART00000098476.6

Conserved Domains (2) summary

cd08767
Location:544 → 669

Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

pfam08839
Location:321 → 484

CDT1; DNA replication factor CDT1 like
XM_017357105.3 → XP_017212594.1 DNA replication factor Cdt1 isoform X2

UniProtKB/TrEMBL

A0A8M6YZJ1