U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Slc24a1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 214111, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Slc24a1provided by MGI
    Official Full Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 1provided by MGI
    Primary source
    MGI:MGI:2384871
    See related
    Ensembl:ENSMUSG00000034452 AllianceGenome:MGI:2384871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis; monoatomic cation transmembrane transport; and regulation of synaptic plasticity. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in brain; lens epithelium; and retina nuclear layer. Used to study congenital stationary night blindness 1D. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1D. Orthologous to human SLC24A1 (solute carrier family 24 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Slc24a1 in Genome Data Viewer
    Location:
    9 C; 9 35.0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64830143..64858902, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64922861..64951620, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36459 Neighboring gene STARR-positive B cell enhancer ABC_E1116 Neighboring gene DENN domain containing 4A Neighboring gene predicted gene, 24347 Neighboring gene predicted gene, 39361 Neighboring gene STARR-positive B cell enhancer ABC_E1789 Neighboring gene integrator complex subunit 14 Neighboring gene predicted gene, 25640 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Vinberg F, et al. Hum Mol Genet, 2015 Oct 15. PMID 26246500, Free PMC Article
    2. Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca(2+) uptake in photoreceptor mitochondria. Bisbach CM, et al. Sci Rep, 2020 Sep 29. PMID 32994451, Free PMC Article
    3. Expression of potassium-dependent sodium-calcium exchanger in the murine lens. De Maria A, et al. Exp Eye Res, 2018 Feb. PMID 29128492, Free PMC Article
    4. Sodium/calcium exchanger expression in the mouse and rat olfactory systems. Pyrski M, et al. J Comp Neurol, 2007 Apr 20. PMID 17311327
    5. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Jia L, et al. Proc Natl Acad Sci U S A, 2009 Oct 13. PMID 19805139, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC27617

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium, potassium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term synaptic depression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    sodium/potassium/calcium exchanger 1
    Names
    Na(+)/K(+)/Ca(2+)-exchange protein 1
    retinal rod Na-Ca+K exchanger
    solute carrier family 24 member 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410501.1 → NP_001397430.1  sodium/potassium/calcium exchanger 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140243

    2. NM_144813.3 → NP_659062.1  sodium/potassium/calcium exchanger 1 isoform 1

      See identical proteins and their annotated locations for NP_659062.1

      Status: VALIDATED

      Source sequence(s)
      AC140243
      Consensus CDS
      CCDS23283.1
      UniProtKB/Swiss-Prot
      Q91WD8
      Related
      ENSMUSP00000035616.8, ENSMUST00000037798.8
      Conserved Domains (1) summary
      TIGR00927
      Location:1 → 1130
      2A1904; K+-dependent Na+/Ca+ exchanger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64830143..64858902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313271.2 → XP_017168760.1  sodium/potassium/calcium exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      Q91WD8
      Conserved Domains (1) summary
      TIGR00927
      Location:1 → 1130
      2A1904; K+-dependent Na+/Ca+ exchanger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WD8.1 GenPept UniProtKB/Swiss-Prot:Q91WD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous