Tmx2 thioredoxin-related transmembrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmx2provided by MGI
Official Full Name: thioredoxin-related transmembrane protein 2provided by MGI
Primary source: MGI:MGI:1914208
See related: Ensembl:ENSMUSG00000050043 AllianceGenome:MGI:1914208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Txndc14; 2310042M24Rik
Summary: Predicted to enable disulfide oxidoreductase activity and identical protein binding activity. Predicted to be involved in brain development. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be active in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human TMX2 (thioredoxin related transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 57.2), frontal lobe adult (RPKM 37.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.45 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84501655..84509172, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (84671311..84678828, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125025 (e-PCR)
- UniSTS:161847

NoName (e-PCR)
- UniSTS:493175

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables disulfide oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables disulfide oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin-related transmembrane protein 2

Names: thioredoxin domain containing 14; thioredoxin domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290751.1 → NP_001277680.1 thioredoxin-related transmembrane protein 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. The 5' UTR of this variant is incomplete due to lack of a complete transcript and splice pattern ambiguity in the upstream region.

Source sequence(s)

AK009759, BQ840236, BY386749

Consensus CDS

CCDS71087.1

UniProtKB/TrEMBL

D3Z2J6

Related

ENSMUSP00000107293.2, ENSMUST00000111664.8

Conserved Domains (1) summary

cd02962
Location:83 → 221

TMX2; TMX2 family; composed of proteins similar to human TMX2, a 372-amino acid TRX-related transmembrane protein, identified and characterized through the cloning of its cDNA from a human fetal library. It contains a TRX domain but the redox active CXXC motif ...
NM_025868.4 → NP_080144.1 thioredoxin-related transmembrane protein 2 isoform a precursor

See identical proteins and their annotated locations for NP_080144.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK009759, AK075750, BQ840236, BY386749

Consensus CDS

CCDS16188.1

UniProtKB/Swiss-Prot

Q8BW13, Q9D710

Related

ENSMUSP00000107294.2, ENSMUST00000111665.8

Conserved Domains (1) summary

cd02962
Location:109 → 259

TMX2; TMX2 family; composed of proteins similar to human TMX2, a 372-amino acid TRX-related transmembrane protein, identified and characterized through the cloning of its cDNA from a human fetal library. It contains a TRX domain but the redox active CXXC motif ...