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    Adcy3 adenylate cyclase 3 [ Mus musculus (house mouse) ]

    Gene ID: 104111, updated on 3-Dec-2024

    Summary

    Official Symbol
    Adcy3provided by MGI
    Official Full Name
    adenylate cyclase 3provided by MGI
    Primary source
    MGI:MGI:99675
    See related
    Ensembl:ENSMUSG00000020654 AllianceGenome:MGI:99675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AC3; ACIII; mKIAA0511
    Summary
    Enables adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and olfactory learning. Acts upstream of or within sensory perception of smell. Located in ciliary membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study major depressive disorder. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 11.6), ovary adult (RPKM 9.6) and 24 other tissues See more
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    Genomic context

    See Adcy3 in Genome Data Viewer
    Location:
    12 A1.1; 12 1.99 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4183397..4263525)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4133116..4213525)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:3981365-3981666 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3982390-3982573 Neighboring gene EFR3 homolog B Neighboring gene STARR-seq mESC enhancer starr_31433 Neighboring gene STARR-positive B cell enhancer mm9_chr12:4082834-4083134 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene predicted gene, 53749 Neighboring gene STARR-seq mESC enhancer starr_31436 Neighboring gene centromere protein O Neighboring gene ubiquitin associated protein 2-like pseudogene Neighboring gene predicted gene, 29696 Neighboring gene peptidyl-tRNA hydrolase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cAMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to forskolin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to forskolin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of smell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    adenylate cyclase type 3
    Names
    AC-III
    ATP pyrophosphate-lyase 3
    adenylate cyclase type III
    adenylate cyclase, olfactive type
    adenylyl cyclase 3
    NP_001153008.1
    NP_001153009.1
    NP_001409715.1
    NP_612178.2
    XP_006514997.1
    XP_006514998.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159536.1NP_001153008.1  adenylate cyclase type 3 isoform 2

      See identical proteins and their annotated locations for NP_001153008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK122298, CF532558
      Consensus CDS
      CCDS49017.1
      UniProtKB/TrEMBL
      B8JK56, Q6PGC0
      Related
      ENSMUSP00000122073.2, ENSMUST00000124505.8
      Conserved Domains (3) summary
      smart00044
      Location:8831101
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9141121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    2. NM_001159537.1NP_001153009.1  adenylate cyclase type 3 isoform 2

      See identical proteins and their annotated locations for NP_001153009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK122298, CF532558
      Consensus CDS
      CCDS49017.1
      UniProtKB/TrEMBL
      B8JK56, Q6PGC0
      Related
      ENSMUSP00000115644.2, ENSMUST00000152065.8
      Conserved Domains (3) summary
      smart00044
      Location:8831101
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:9141121
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    3. NM_001422786.1NP_001409715.1  adenylate cyclase type 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT572999
      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      UniProtKB/TrEMBL
      Q6PGC0
      Related
      ENSMUST00000152792.8
    4. NM_138305.4NP_612178.2  adenylate cyclase type 3 isoform 1

      See identical proteins and their annotated locations for NP_612178.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CT572999
      Consensus CDS
      CCDS25787.1
      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      UniProtKB/TrEMBL
      Q6PGC0
      Conserved Domains (2) summary
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4183397..4263525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514934.5XP_006514997.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514997.1

      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      UniProtKB/TrEMBL
      Q6PGC0
      Related
      ENSMUSP00000020984.8, ENSMUST00000020984.9
      Conserved Domains (2) summary
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    2. XM_006514935.5XP_006514998.1  adenylate cyclase type 3 isoform X1

      See identical proteins and their annotated locations for XP_006514998.1

      UniProtKB/Swiss-Prot
      B8JK57, Q8VHH7
      UniProtKB/TrEMBL
      Q6PGC0
      Related
      ENSMUSP00000115406.2, ENSMUST00000127756.8
      Conserved Domains (2) summary
      pfam00211
      Location:9151122
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:44303
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region