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    Syt8 synaptotagmin VIII [ Mus musculus (house mouse) ]

    Gene ID: 55925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syt8provided by MGI
    Official Full Name
    synaptotagmin VIIIprovided by MGI
    Primary source
    MGI:MGI:1859867
    See related
    Ensembl:ENSMUSG00000031098 AllianceGenome:MGI:1859867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables calcium-dependent protein binding activity. Involved in acrosome reaction. Located in cytoplasm and vesicle. Is expressed in bladder. Orthologous to human SYT8 (synaptotagmin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 74.9), bladder adult (RPKM 52.7) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syt8 in Genome Data Viewer
    Location:
    7 F5; 7 87.93 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141988195..141994136)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142434850..142440396)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149567080-149567427 Neighboring gene STARR-seq mESC enhancer starr_20506 Neighboring gene cathepsin D Neighboring gene predicted gene, 26143 Neighboring gene STARR-seq mESC enhancer starr_20508 Neighboring gene troponin I, skeletal, fast 2 Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene lymphocyte specific 1 Neighboring gene proline rich 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inositol 1,3,4,5-tetrakisphosphate binding activities of neuronal and non-neuronal synaptotagmins. Identification of conserved amino acid substitutions that abolish inositol 1,3,4,5-tetrakisphosphate binding to synaptotagmins III, V, and X. Ibata K, et al. J Biol Chem, 1998 May 15. PMID 9575177
    2. Calcium-dependent and -independent hetero-oligomerization in the synaptotagmin family. Fukuda M, et al. J Biochem, 2000 Oct. PMID 11011146
    3. Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. Monterrat C, et al. Biochim Biophys Acta, 2006 Jan. PMID 16386321
    4. Synaptotagmin VIII is localized to the mouse sperm head and may function in acrosomal exocytosis. Hutt DM, et al. Biol Reprod, 2002 Jan. PMID 11751263
    5. Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction. Hutt DM, et al. J Biol Chem, 2005 May 27. PMID 15774481

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Syt VIII is a candidate for the Ca(2+) sensor that regulates acrosomal exocytosis in mammalian sperm
      Title: Synaptotagmin VIII is localized to the mouse sperm head and may function in acrosomal exocytosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124104, MGC124105

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome reaction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dense core granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptotagmin-8
    Names
    sytVIII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285857.1 → NP_001272786.1  synaptotagmin-8 isoform b

      See identical proteins and their annotated locations for NP_001272786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AK075832
      Consensus CDS
      CCDS72071.1
      UniProtKB/TrEMBL
      F2Z3W8, Q496Q3
      Related
      ENSMUSP00000101596.2, ENSMUST00000105976.8
      Conserved Domains (1) summary
      cl14603
      Location:236 → 366
      C2; C2 domain

    2. NM_001285858.1 → NP_001272787.1  synaptotagmin-8 isoform b

      See identical proteins and their annotated locations for NP_001272787.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AK075832
      Consensus CDS
      CCDS72071.1
      UniProtKB/TrEMBL
      F2Z3W8, Q496Q3
      Related
      ENSMUSP00000095552.3, ENSMUST00000097939.9
      Conserved Domains (1) summary
      cl14603
      Location:236 → 366
      C2; C2 domain

    3. NM_001285861.1 → NP_001272790.1  synaptotagmin-8 isoform c

      See identical proteins and their annotated locations for NP_001272790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AK075832, AL603651
      Consensus CDS
      CCDS72070.1
      UniProtKB/Swiss-Prot
      A9JAL0, Q64366, Q8C6E7, Q9R0N6
      UniProtKB/TrEMBL
      Q496Q3
      Related
      ENSMUSP00000112689.2, ENSMUST00000122393.2
      Conserved Domains (2) summary
      cl14603
      Location:242 → 372
      C2; C2 domain
      cl25995
      Location:49 → 82
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    4. NM_018802.5 → NP_061272.2  synaptotagmin-8 isoform a

      See identical proteins and their annotated locations for NP_061272.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK075832
      Consensus CDS
      CCDS22030.1
      UniProtKB/TrEMBL
      Q496Q3
      Related
      ENSMUSP00000113545.2, ENSMUST00000118276.8
      Conserved Domains (1) summary
      cl14603
      Location:242 → 372
      C2; C2 domain

    RNA

    1. NR_153437.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA023701, AL603651

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141988195..141994136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153263.1 → XP_036009156.1  synaptotagmin-8 isoform X6

      Conserved Domains (1) summary
      cl14603
      Location:122 → 240
      C2; C2 domain

    2. XM_036153264.1 → XP_036009157.1  synaptotagmin-8 isoform X7

      Conserved Domains (1) summary
      cl14603
      Location:122 → 240
      C2; C2 domain

    3. XM_036153265.1 → XP_036009158.1  synaptotagmin-8 isoform X8

      Conserved Domains (1) summary
      cl14603
      Location:122 → 240
      C2; C2 domain

    4. XM_006508632.5 → XP_006508695.1  synaptotagmin-8 isoform X1

      See identical proteins and their annotated locations for XP_006508695.1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (1) summary
      cl14603
      Location:249 → 379
      C2; C2 domain

    5. XM_006508633.5 → XP_006508696.1  synaptotagmin-8 isoform X1

      See identical proteins and their annotated locations for XP_006508696.1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (1) summary
      cl14603
      Location:249 → 379
      C2; C2 domain

    6. XM_011242014.4 → XP_011240316.1  synaptotagmin-8 isoform X2

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (2) summary
      cl14603
      Location:248 → 378
      C2; C2 domain
      cl25995
      Location:55 → 88
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    7. XM_006508638.4 → XP_006508701.1  synaptotagmin-8 isoform X3

      See identical proteins and their annotated locations for XP_006508701.1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (2) summary
      cl14603
      Location:243 → 373
      C2; C2 domain
      cl25995
      Location:50 → 83
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    8. XM_006508639.4 → XP_006508702.1  synaptotagmin-8 isoform X3

      See identical proteins and their annotated locations for XP_006508702.1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (2) summary
      cl14603
      Location:243 → 373
      C2; C2 domain
      cl25995
      Location:50 → 83
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    9. XM_011242015.4 → XP_011240317.1  synaptotagmin-8 isoform X3

      See identical proteins and their annotated locations for XP_011240317.1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (2) summary
      cl14603
      Location:243 → 373
      C2; C2 domain
      cl25995
      Location:50 → 83
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    10. XM_006508635.5 → XP_006508698.1  synaptotagmin-8 isoform X3

      See identical proteins and their annotated locations for XP_006508698.1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (2) summary
      cl14603
      Location:243 → 373
      C2; C2 domain
      cl25995
      Location:50 → 83
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    11. XM_006508637.5 → XP_006508700.1  synaptotagmin-8 isoform X3

      See identical proteins and their annotated locations for XP_006508700.1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (2) summary
      cl14603
      Location:243 → 373
      C2; C2 domain
      cl25995
      Location:50 → 83
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    12. XM_036153262.1 → XP_036009155.1  synaptotagmin-8 isoform X5

      UniProtKB/TrEMBL
      Q496Q4
      Conserved Domains (1) summary
      cl14603
      Location:138 → 268
      C2; C2 domain

    13. XM_011242016.4 → XP_011240318.1  synaptotagmin-8 isoform X4

      See identical proteins and their annotated locations for XP_011240318.1

      UniProtKB/Swiss-Prot
      A9JAL0, Q64366, Q8C6E7, Q9R0N6
      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (2) summary
      cl14603
      Location:242 → 372
      C2; C2 domain
      cl25995
      Location:49 → 82
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    14. XM_036153261.1 → XP_036009154.1  synaptotagmin-8 isoform X1

      UniProtKB/TrEMBL
      Q496Q3
      Conserved Domains (1) summary
      cl14603
      Location:249 → 379
      C2; C2 domain

    RNA

    1. XR_004934155.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0N6.1 GenPept UniProtKB/Swiss-Prot:Q9R0N6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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