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    Nhlrc3 NHL repeat containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 212114, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nhlrc3provided by MGI
    Official Full Name
    NHL repeat containing 3provided by MGI
    Primary source
    MGI:MGI:2444520
    See related
    Ensembl:ENSMUSG00000042997 AllianceGenome:MGI:2444520
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4083; 4833441N19; 8030451K01Rik
    Summary
    Predicted to enable translation repressor activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of translation; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Is expressed in embryo. Orthologous to human NHLRC3 (NHL repeat containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.8), colon adult (RPKM 5.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nhlrc3 in Genome Data Viewer
    Location:
    3 C; 3 25.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (53359417..53370679, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (53451996..53463258, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40048 Neighboring gene predicted gene 43471 Neighboring gene STARR-seq mESC enhancer starr_07655 Neighboring gene STARR-seq mESC enhancer starr_07656 Neighboring gene predicted gene 16206 Neighboring gene STARR-seq mESC enhancer starr_07657 Neighboring gene proline and serine rich 1 Neighboring gene stomatin (Epb7.2)-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Clone Names

    • KIAA4083, MGC107225, MGC130333

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NHL repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172501.2NP_766089.1  NHL repeat-containing protein 3 precursor

      See identical proteins and their annotated locations for NP_766089.1

      Status: PROVISIONAL

      Source sequence(s)
      AK033167
      Consensus CDS
      CCDS17345.1
      UniProtKB/Swiss-Prot
      Q8CCH2, Q8CDW5
      Related
      ENSMUSP00000055295.8, ENSMUST00000056749.14
      Conserved Domains (3) summary
      COG3391
      Location:66308
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd05819
      Location:107153
      NHL; NHL repeat [structural motif]
      cl18310
      Location:66336
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      53359417..53370679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)