Casp3 caspase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Casp3provided by RGD
Official Full Name: caspase 3provided by RGD
Primary source: RGD:2275
See related: EnsemblRapid:ENSRNOG00000010475 AllianceGenome:RGD:2275
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lice; Yama; CPP32-beta
Summary: Enables several functions, including death receptor binding activity; phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including nervous system development; positive regulation of amyloid-beta formation; and response to anesthetic. Located in neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 222.5), Spleen (RPKM 187.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (52395539..52413794, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (45662910..45681171, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (48845011..48863249, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells.
Title: A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells.
Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
Title: Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life.
Title: Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life.
Expression of active caspase 3 in the rat lens after in vivo exposure to subthreshold dose of UVR-B.
Title: Expression of active caspase 3 in the rat lens after in vivo exposure to subthreshold dose of UVR-B.
Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling.
Title: Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling.
Cardiopulmonary bypass in a rat model may shorten the lifespan of stored red blood cells by activating caspase-3.
Title: Cardiopulmonary bypass in a rat model may shorten the lifespan of stored red blood cells by activating caspase-3.
Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Title: Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Myonuclear apoptosis via cleaved caspase-3 upregulation is related to macrophage accumulation underlying immobilization-induced muscle fibrosis.
Title: Myonuclear apoptosis via cleaved caspase-3 upregulation is related to macrophage accumulation underlying immobilization-induced muscle fibrosis.
Effect of l-carnitine supplementation on lead acetate-induced liver cell apoptosis and inflammation: role of caspase-3 and glycogen synthase kinase-3beta enzymes.
Title: Effect of l-carnitine supplementation on lead acetate-induced liver cell apoptosis and inflammation: role of caspase-3 and glycogen synthase kinase-3β enzymes.
VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation.
Title: VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation.

Submit: New GeneRIF Correction See all GeneRIFs (256)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Casp3 (e-PCR), detects polymorphism
- UniSTS:259200

PMC148819P9 (e-PCR)
- UniSTS:271022

RH133488 (e-PCR)
- UniSTS:216771

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables death receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to staurosporine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in glial cell apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to anesthetic	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to auditory stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to cobalt ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in striated muscle cell differentiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-3

Names: CASP-3; CPP-32; CPP32beta; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); IRP; SCA-1; SREBP cleavage activity 1; apopain; cysteine protease CPP32; cysteine protease p32-beta; protein Yama

NP_037054.1

EC 3.4.22.56

XP_006253192.1

EC 3.4.22.56

XP_038950133.1

EC 3.4.22.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012922.2 → NP_037054.1 caspase-3

See identical proteins and their annotated locations for NP_037054.1

Status: PROVISIONAL

Source sequence(s)

BC081854

UniProtKB/Swiss-Prot

P55213, P70543, P97699, Q62993

UniProtKB/TrEMBL

A6JPM9

Related

ENSRNOP00000014096.3, ENSRNOT00000014095.7

Conserved Domains (1) summary

smart00115
Location:37 → 277

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

52395539..52413794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253130.5 → XP_006253192.1 caspase-3 isoform X1

See identical proteins and their annotated locations for XP_006253192.1

UniProtKB/Swiss-Prot

P55213, P70543, P97699, Q62993

UniProtKB/TrEMBL

A6JPM9

Conserved Domains (1) summary

smart00115
Location:37 → 277

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
XM_039094205.2 → XP_038950133.1 caspase-3 isoform X2

Conserved Domains (1) summary

cl00042
Location:37 → 206

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...