Mfsd8 major facilitator superfamily domain containing 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mfsd8provided by RGD
Official Full Name: major facilitator superfamily domain containing 8provided by RGD
Primary source: RGD:1310132
See related: EnsemblRapid:ENSRNOG00000012729 AllianceGenome:RGD:1310132
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ab2-276; RGD1310132
Summary: Predicted to enable chloride channel activity; fluoride channel activity; and iodide transmembrane transporter activity. Predicted to be involved in autophagosome maturation and lysosome organization. Predicted to act upstream of or within several processes, including TORC1 signaling; determination of adult lifespan; and neurogenesis. Predicted to be located in endosome membrane and lysosome. Predicted to be active in lysosomal membrane and mitochondrion. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 72.0), Muscle (RPKM 71.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (125749994..125784689, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (123822042..123847808, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (127706618..127784129, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables fluoride channel activity	ISO Inferred from Sequence Orthology more info
enables iodide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables iodide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagosome maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in fluoride transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gliogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in iodide transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of location	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microglia differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: major facilitator superfamily domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393796.1 → NP_001380725.1 major facilitator superfamily domain-containing protein 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6ANA0

Related

ENSRNOP00000070612.3, ENSRNOT00000087535.3

Conserved Domains (1) summary

cd17326
Location:40 → 508

MFS_MFSD8; Major facilitator superfamily domain-containing protein 8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

125749994..125784689 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282062.1 → XP_063138132.1 major facilitator superfamily domain-containing protein 8 isoform X1

UniProtKB/TrEMBL

A0A8I6ANA0
XM_039102591.2 → XP_038958519.1 major facilitator superfamily domain-containing protein 8 isoform X3

UniProtKB/TrEMBL

A0A8I5ZZ73

Conserved Domains (1) summary

cd17326
Location:32 → 422

MFS_MFSD8; Major facilitator superfamily domain-containing protein 8
XM_063282065.1 → XP_063138135.1 major facilitator superfamily domain-containing protein 8 isoform X5
XM_063282063.1 → XP_063138133.1 major facilitator superfamily domain-containing protein 8 isoform X2

UniProtKB/TrEMBL

A0A8I6ANA0
XM_063282064.1 → XP_063138134.1 major facilitator superfamily domain-containing protein 8 isoform X3

UniProtKB/TrEMBL

A0A8I5ZZ73
XM_063282066.1 → XP_063138136.1 major facilitator superfamily domain-containing protein 8 isoform X6
XM_039102592.2 → XP_038958520.1 major facilitator superfamily domain-containing protein 8 isoform X4

Conserved Domains (1) summary

cd17326
Location:1 → 373

MFS_MFSD8; Major facilitator superfamily domain-containing protein 8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001047910.1: Suppressed sequence

Description

NM_001047910.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.