Spop speckle type BTB/POZ protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spopprovided by RGD
Official Full Name: speckle type BTB/POZ proteinprovided by RGD
Primary source: RGD:1311613
See related: EnsemblRapid:ENSRNOG00000004686 AllianceGenome:RGD:1311613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of proteolysis. Predicted to act upstream of or within several processes, including glucose homeostasis; positive regulation of apoptotic process; and regulation of DNA-templated transcription. Predicted to be located in nuclear speck. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 246.0), Heart (RPKM 198.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80854890..80935781)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (80358121..80438983)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (83231187..83311987)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

BE104182 (e-PCR)
- UniSTS:245303

MARC_9787-9788:996688611:1 (e-PCR)
- UniSTS:270001

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: speckle-type POZ protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100496.2 → NP_001093966.1 speckle-type POZ protein

See identical proteins and their annotated locations for NP_001093966.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9, F7EK37

Conserved Domains (3) summary

cd03774
Location:28 → 166

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd18279
Location:182 → 301

BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins

cd18518
Location:297 → 367

BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

80854890..80935781

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085596.2 → XP_038941524.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9, F7EK37

Conserved Domains (3) summary

cd03774
Location:28 → 166

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd18279
Location:182 → 301

BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins

cd18518
Location:297 → 367

BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
XM_039085592.2 → XP_038941520.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9, F7EK37

Conserved Domains (3) summary

cd03774
Location:28 → 166

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd18279
Location:182 → 301

BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins

cd18518
Location:297 → 367

BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
XM_063268721.1 → XP_063124791.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_008767968.3 → XP_008766190.1 speckle-type POZ protein isoform X1

See identical proteins and their annotated locations for XP_008766190.1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9, F7EK37

Related

ENSRNOP00000006230.5, ENSRNOT00000006230.7

Conserved Domains (3) summary

cd03774
Location:28 → 166

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd18279
Location:182 → 301

BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins

cd18518
Location:297 → 367

BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
XM_063268712.1 → XP_063124782.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268722.1 → XP_063124792.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268723.1 → XP_063124793.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268714.1 → XP_063124784.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_039085597.2 → XP_038941525.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9, F7EK37

Conserved Domains (3) summary

cd03774
Location:28 → 166

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd18279
Location:182 → 301

BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins

cd18518
Location:297 → 367

BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
XM_017597130.3 → XP_017452619.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9, F7EK37

Conserved Domains (3) summary

cd03774
Location:28 → 166

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd18279
Location:182 → 301

BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins

cd18518
Location:297 → 367

BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
XM_063268713.1 → XP_063124783.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9

Related

ENSRNOP00000084460.1, ENSRNOT00000100446.2
XM_063268711.1 → XP_063124781.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268716.1 → XP_063124786.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_039085600.2 → XP_038941528.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9, F7EK37

Conserved Domains (3) summary

cd03774
Location:28 → 166

MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...

cd18279
Location:182 → 301

BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins

cd18518
Location:297 → 367

BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)
XM_063268724.1 → XP_063124794.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268717.1 → XP_063124787.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268719.1 → XP_063124789.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268718.1 → XP_063124788.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268720.1 → XP_063124790.1 speckle-type POZ protein isoform X1

UniProtKB/TrEMBL

A0A8I6GAF0, A6HIA2, B2RYD9
XM_063268725.1 → XP_063124795.1 speckle-type POZ protein isoform X2