Fosl1 FOS like 1, AP-1 transcription factor subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fosl1provided by RGD
Official Full Name: FOS like 1, AP-1 transcription factor subunitprovided by RGD
Primary source: RGD:2627
See related: EnsemblRapid:ENSRNOG00000072086 AllianceGenome:RGD:2627
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fra-1; fra-1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of DNA-templated transcription; response to corticosterone; and response to progesterone. Located in presynaptic membrane. Biomarker of congestive heart failure and renal carcinoma. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 21.9), Lung (RPKM 19.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (212183885..212192391)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (202754549..202763057)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (220826560..220835066)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOSL1 modulates Schwann cell responses in the wound microenvironment and regulates peripheral nerve regeneration.
Title: FOSL1 modulates Schwann cell responses in the wound microenvironment and regulates peripheral nerve regeneration.
Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
Title: Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
Identification of the Fosl1/AMPK/autophagy axis involved in apoptotic and inflammatory effects following spinal cord injury.
Title: Identification of the Fosl1/AMPK/autophagy axis involved in apoptotic and inflammatory effects following spinal cord injury.
results identify that Fra-1 plays a novel and key role in promoting vascular aging by directly binding and transcriptionally activating p21 and p16 signaling, suggesting intervention of Fra-1 is a potential strategy for preventing aging-associated cardiovascular disorders
Title: Fra-1 plays a critical role in angiotensin II-induced vascular senescence.
FOSL1 recruits JUNB to form AP-1 transcriptional complexes that specifically regulate the endocrine and invasive trophoblast phenotypes.
Title: Dynamic Regulation of AP-1 Transcriptional Complexes Directs Trophoblast Differentiation.
is regulated in cardia myoblasts by cellular redox through multiple cis-regulatory modules
Title: In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules.
FOSL1 is integral to establishing the maternal-fetal interface
Title: FOSL1 is integral to establishing the maternal-fetal interface.
Data show that bladder wall distension leads to PDGF receptor activation and identify thrombomodulin as an Akt and Fra-1 target in smooth muscle cells.
Title: An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration.
Corticosterone produced an early and transient reduction of fra-1 mRNA levels exclusively in the rat dentate gyrus.
Title: Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.
plays key role in remodelling phenomena of bone and cartilage
Title: Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

Fosl1 (e-PCR), detects polymorphism
- UniSTS:256611

Fosl1 (e-PCR), detects polymorphism
- UniSTS:256612

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in learning	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within placenta blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vitellogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fos-related antigen 1

Names: FOS like 1, AP-1 trancription factor subunit; fos-like antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012953.2 → NP_037085.1 fos-related antigen 1

See identical proteins and their annotated locations for NP_037085.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P10158, Q4V8K7

UniProtKB/TrEMBL

A6HZ58

Related

ENSRNOP00000108693.1, ENSRNOT00000136311.1

Conserved Domains (2) summary

cd14721
Location:117 → 170

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:128 → 247

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)