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    Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rap1gds1provided by RGD
    Official Full Name
    Rap1 GTPase-GDP dissociation stimulator 1provided by RGD
    Primary source
    RGD:1308558
    See related
    EnsemblRapid:ENSRNOG00000015987 AllianceGenome:RGD:1308558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in myosin filament assembly; positive regulation of GTPase activity; and vascular associated smooth muscle contraction. Predicted to be located in several cellular components, including endoplasmic reticulum; extracellular space; and mitochondrion. Predicted to be active in cytosol. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 234.3), Kidney (RPKM 77.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rap1gds1 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (230173713..230318555, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (227500366..227645213, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (244258550..244370983, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene CRACD-like protein Neighboring gene tetraspanin 5 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 20 Neighboring gene uncharacterized LOC120100955 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation. Ravichandran A, et al. Mol Biol Cell, 2013 Jan. PMID 23155002, Free PMC Article
    2. Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells. Thill R, et al. J Cell Biochem, 2008 Aug 1. PMID 18348285
    3. betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth. Shin EY, et al. J Biol Chem, 2006 Nov 24. PMID 16954223
    4. Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1. Hsieh YF, et al. PLoS One, 2013. PMID 24349085, Free PMC Article
    5. Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells. Schönherr C, et al. Oncogene, 2010 May 13. PMID 20190816

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SmgGDS, a novel Ras regulator, suppresses Ras-BPGAP1-induced Ras/ERK activation.
      Title: SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation.
    2. ALK activation of Rap1 via the Rap1-specific GEF C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma.
      Title: Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.
    3. These results identify SmgGDS as a novel regulator of myosin organization and contraction in vascular smooth muscle cells.
      Title: Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells.
    4. betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth
      Title: betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAAX-box protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myosin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of ERK5 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of matrix metallopeptidase secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rap1 GTPase-GDP dissociation stimulator 1
    Names
    RAP1, GTP-GDP dissociation stimulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107728.3 → NP_001101198.2  rap1 GTPase-GDP dissociation stimulator 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HW43, F1M7Y3
      Related
      ENSRNOP00000021457.7, ENSRNOT00000021458.9

    2. NM_001415062.2 → NP_001401991.1  rap1 GTPase-GDP dissociation stimulator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K1D2, A6HW44
      Related
      ENSRNOP00000071795.2, ENSRNOT00000084860.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      230173713..230318555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102470.2 → XP_038958398.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

      UniProtKB/TrEMBL
      A6HW44
      Conserved Domains (4) summary
      smart00185
      Location:346 → 389
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:18 → 264
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:91 → 116
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:86 → 117
      Arm; Armadillo/beta-catenin-like repeat

    2. XM_039102469.2 → XP_038958397.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X2

      UniProtKB/TrEMBL
      A6HW44
      Conserved Domains (4) summary
      smart00185
      Location:346 → 389
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:18 → 264
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:91 → 116
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:86 → 117
      Arm; Armadillo/beta-catenin-like repeat

    3. XM_063281978.1 → XP_063138048.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X4

      UniProtKB/TrEMBL
      A6HW43

    4. XM_039102473.2 → XP_038958401.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X3

      UniProtKB/TrEMBL
      A6HW43
      Conserved Domains (3) summary
      smart00185
      Location:297 → 340
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:44 → 71
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:86 → 117
      Arm; Armadillo/beta-catenin-like repeat

    5. XM_039102477.2 → XP_038958405.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X5

      UniProtKB/TrEMBL
      A6HW43
      Conserved Domains (2) summary
      smart00185
      Location:168 → 211
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:173 → 212
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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