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    Syde2 synapse defective Rho GTPase homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syde2provided by RGD
    Official Full Name
    synapse defective Rho GTPase homolog 2provided by RGD
    Primary source
    RGD:1564206
    See related
    EnsemblRapid:ENSRNOG00000026186 AllianceGenome:RGD:1564206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Syde2-ps1; RGD1564206
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in cell migration and regulation of Ras protein signal transduction. Predicted to be active in synaptic membrane. Orthologous to human SYDE2 (synapse defective Rho GTPase homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 64.7), Lung (RPKM 55.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Syde2 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (237557395..237591290)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (234897975..234930994)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (251861900..251895524)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485992 Neighboring gene RNA, U5E small nuclear 5 Neighboring gene mucolipin TRP cation channel 3 Neighboring gene dynein axonemal intermediate chain 3 Neighboring gene mucolipin TRP cation channel 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion. Lo HF, et al. J Pathol, 2017 Feb. PMID 27917469
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein SYDE2
    Names
    synapse defective 1, Rho GTPase, homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305229.2 → NP_001292158.2  rho GTPase-activating protein SYDE2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWC8
      Related
      ENSRNOP00000031789.8, ENSRNOT00000036282.8
      Conserved Domains (3) summary
      PHA03247
      Location:115 → 324
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:901 → 1115
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14603
      Location:766 → 881
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      237557395..237591290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281682.1 → XP_063137752.1  rho GTPase-activating protein SYDE2 isoform X4

    2. XM_039102136.2 → XP_038958064.1  rho GTPase-activating protein SYDE2 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:115 → 287
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:902 → 1116
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14603
      Location:767 → 882
      C2; C2 domain

    3. XM_017590812.3 → XP_017446301.2  rho GTPase-activating protein SYDE2 isoform X1

      UniProtKB/TrEMBL
      A6HWC8, F1LVD8
      Conserved Domains (3) summary
      PHA03247
      Location:115 → 324
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:902 → 1116
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14603
      Location:767 → 882
      C2; C2 domain

    4. XM_039102135.2 → XP_038958063.1  rho GTPase-activating protein SYDE2 isoform X2

      UniProtKB/TrEMBL
      A6HWC8
      Conserved Domains (3) summary
      PHA03247
      Location:115 → 324
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:869 → 1059
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14603
      Location:769 → 836
      C2; C2 domain

    5. XM_017590814.3 → XP_017446303.2  rho GTPase-activating protein SYDE2 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:115 → 287
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:902 → 1116
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14603
      Location:767 → 882
      C2; C2 domain

    6. XM_039102137.2 → XP_038958065.1  rho GTPase-activating protein SYDE2 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:115 → 287
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:902 → 1116
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl14603
      Location:767 → 882
      C2; C2 domain

    RNA

    1. XR_005500274.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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