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    Samd4a sterile alpha motif domain containing 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Samd4aprovided by RGD
    Official Full Name
    sterile alpha motif domain containing 4Aprovided by RGD
    Primary source
    RGD:1310361
    See related
    EnsemblRapid:ENSRNOG00000010489 AllianceGenome:RGD:1310361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Samd4
    Summary
    Predicted to enable mRNA binding activity and translation repressor activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SAMD4A (sterile alpha motif domain containing 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 80.2), Heart (RPKM 53.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Samd4a in Genome Data Viewer
    Location:
    15p14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (22616200..22831872)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20135994..20352131)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (23666543..23879067)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene ribosomal protein L39, pseudogene 11 Neighboring gene uncharacterized LOC102548367 Neighboring gene GTP cyclohydrolase 1 Neighboring gene uncharacterized LOC102548428

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation. Baez MV, et al. J Cell Biol, 2011 Dec 26. PMID 22201125, Free PMC Article
    2. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. Baez MV, et al. J Biol Chem, 2005 Dec 30. PMID 16221671
    3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Smaug homolog 1
    Names
    smaug 1
    sterile alpha motif domain containing 4
    sterile alpha motif domain-containing protein 4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399774.2 → NP_001386703.1  protein Smaug homolog 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      B5DF21
      UniProtKB/TrEMBL
      A0A0G2JVW7, A6KE35
      Related
      ENSRNOP00000102658.1, ENSRNOT00000125727.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      22616200..22831872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093258.2 → XP_038949186.1  protein Smaug homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUK8, A0A0G2JVW7, A6KE35
      Related
      ENSRNOP00000069646.3, ENSRNOT00000092091.3
      Conserved Domains (1) summary
      cd09557
      Location:320 → 382
      SAM_Smaug; SAM domain of Smaug subfamily

    2. XM_039093259.2 → XP_038949187.1  protein Smaug homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GLX6, A6KE36
      Related
      ENSRNOP00000096104.1, ENSRNOT00000107922.2
      Conserved Domains (1) summary
      cd09557
      Location:238 → 294
      SAM_Smaug; SAM domain of Smaug subfamily

    3. XM_063274206.1 → XP_063130276.1  protein Smaug homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVW7, A6KE35

    4. XM_063274207.1 → XP_063130277.1  protein Smaug homolog 1 isoform X4

      UniProtKB/TrEMBL
      A6KE36

    5. XM_063274208.1 → XP_063130278.1  protein Smaug homolog 1 isoform X5

    6. XM_039093261.2 → XP_038949189.1  protein Smaug homolog 1 isoform X6

      UniProtKB/TrEMBL
      A6KE37

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107254.1: Suppressed sequence

      Description
      NM_001107254.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DF21.1 GenPept UniProtKB/Swiss-Prot:B5DF21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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