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    Oplah 5-oxoprolinase (ATP-hydrolysing) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116684, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Oplahprovided by RGD
    Official Full Name
    5-oxoprolinase (ATP-hydrolysing)provided by RGD
    Primary source
    RGD:620956
    See related
    EnsemblRapid:ENSRNOG00000011781 AllianceGenome:RGD:620956
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 5-oxoprolinase (ATP-hydrolyzing) activity and identical protein binding activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 348.2), Liver (RPKM 107.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Oplah in Genome Data Viewer
    Location:
    7q34
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109892136..109932403, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108011472..108051751, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117353951..117394205, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093816 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene transfer RNA leucine (anticodon AAG) 12 Neighboring gene sphingomyelin phosphodiesterase 5 Neighboring gene exosome component 4 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene cytochrome c-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning. Ye GJ, et al. J Biol Chem, 1996 Dec 13. PMID 8943290
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105359

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5-oxoprolinase (ATP-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-oxoprolinase (ATP-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    5-oxoprolinase
    Names
    5-OPase
    5-oxo-L-prolinase
    pyroglutamase
    NP_446356.1
    XP_006241833.1
    XP_006241834.1
    XP_006241835.1
    XP_006241837.1
    XP_038934184.1
    XP_038934185.1
    XP_038934186.1
    XP_038934187.1
    XP_063118944.1
    XP_063118945.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053904.1 → NP_446356.1  5-oxoprolinase

      Status: PROVISIONAL

      Source sequence(s)
      U70825
      UniProtKB/TrEMBL
      A0A8L2Q8T4
      Related
      ENSRNOP00000074664.1, ENSRNOT00000077314.3
      Conserved Domains (4) summary
      PLN02666
      Location:1 → 1258
      PLN02666; 5-oxoprolinase
      pfam01968
      Location:231 → 513
      Hydantoinase_A; Hydantoinase/oxoprolinase
      pfam02538
      Location:734 → 1256
      Hydantoinase_B; Hydantoinase B/oxoprolinase
      pfam05378
      Location:9 → 212
      Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109892136..109932403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078258.2 → XP_038934186.1  5-oxoprolinase isoform X4

      UniProtKB/Swiss-Prot
      P97608, Q5U3Z8
      UniProtKB/TrEMBL
      A0A8L2Q8T4, A6HS77
      Conserved Domains (1) summary
      PLN02666
      Location:1 → 1258
      PLN02666; 5-oxoprolinase

    2. XM_039078259.2 → XP_038934187.1  5-oxoprolinase isoform X4

      UniProtKB/Swiss-Prot
      P97608, Q5U3Z8
      UniProtKB/TrEMBL
      A0A8L2Q8T4, A6HS77
      Conserved Domains (1) summary
      PLN02666
      Location:1 → 1258
      PLN02666; 5-oxoprolinase

    3. XM_006241775.5 → XP_006241837.1  5-oxoprolinase isoform X4

      UniProtKB/Swiss-Prot
      P97608, Q5U3Z8
      UniProtKB/TrEMBL
      A0A8L2Q8T4, A6HS77
      Conserved Domains (1) summary
      PLN02666
      Location:1 → 1258
      PLN02666; 5-oxoprolinase

    4. XM_039078257.2 → XP_038934185.1  5-oxoprolinase isoform X4

      UniProtKB/Swiss-Prot
      P97608, Q5U3Z8
      UniProtKB/TrEMBL
      A0A8L2Q8T4, A6HS77
      Conserved Domains (1) summary
      PLN02666
      Location:1 → 1258
      PLN02666; 5-oxoprolinase

    5. XM_006241773.5 → XP_006241835.1  5-oxoprolinase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZD3, A0A8L2R932
      Related
      ENSRNOP00000109647.1, ENSRNOT00000156781.1
      Conserved Domains (5) summary
      PLN02666
      Location:97 → 1354
      PLN02666; 5-oxoprolinase
      pfam01968
      Location:327 → 609
      Hydantoinase_A; Hydantoinase/oxoprolinase
      pfam02538
      Location:830 → 1352
      Hydantoinase_B; Hydantoinase B/oxoprolinase
      pfam05378
      Location:105 → 308
      Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
      cl19252
      Location:4 → 44
      MreC; rod shape-determining protein MreC

    6. XM_006241772.5 → XP_006241834.1  5-oxoprolinase isoform X2

      UniProtKB/TrEMBL
      A0A8L2R932
      Conserved Domains (5) summary
      PLN02666
      Location:136 → 1392
      PLN02666; 5-oxoprolinase
      pfam01968
      Location:366 → 648
      Hydantoinase_A; Hydantoinase/oxoprolinase
      pfam02538
      Location:869 → 1390
      Hydantoinase_B; Hydantoinase B/oxoprolinase
      pfam05378
      Location:144 → 347
      Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
      cl19252
      Location:4 → 44
      MreC; rod shape-determining protein MreC

    7. XM_006241771.5 → XP_006241833.1  5-oxoprolinase isoform X1

      UniProtKB/TrEMBL
      A0A8L2R932
      Related
      ENSRNOP00000084556.2, ENSRNOT00000110169.2
      Conserved Domains (5) summary
      PLN02666
      Location:136 → 1393
      PLN02666; 5-oxoprolinase
      pfam01968
      Location:366 → 648
      Hydantoinase_A; Hydantoinase/oxoprolinase
      pfam02538
      Location:869 → 1391
      Hydantoinase_B; Hydantoinase B/oxoprolinase
      pfam05378
      Location:144 → 347
      Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
      cl19252
      Location:4 → 44
      MreC; rod shape-determining protein MreC

    8. XM_039078256.2 → XP_038934184.1  5-oxoprolinase isoform X4

      UniProtKB/Swiss-Prot
      P97608, Q5U3Z8
      UniProtKB/TrEMBL
      A0A8L2Q8T4, A6HS77
      Conserved Domains (1) summary
      PLN02666
      Location:1 → 1258
      PLN02666; 5-oxoprolinase

    9. XM_063262874.1 → XP_063118944.1  5-oxoprolinase isoform X5

      UniProtKB/TrEMBL
      A0A8L2Q8T4

    10. XM_063262875.1 → XP_063118945.1  5-oxoprolinase isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q8T4

    RNA

    1. XR_005486539.2 RNA Sequence

    2. XR_005486538.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97608.2 GenPept UniProtKB/Swiss-Prot:P97608

    Gene LinkOut

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