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    Fbxw11 F-box and WD repeat domain containing 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxw11provided by RGD
    Official Full Name
    F-box and WD repeat domain containing 11provided by RGD
    Primary source
    RGD:1309121
    See related
    EnsemblRapid:ENSRNOG00000004395 AllianceGenome:RGD:1309121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including dynein complex binding activity; microtubule plus-end binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; regulation of DNA-templated transcription; and transport along microtubule. Predicted to be located in centrosome; cytosol; and nucleus. Predicted to be part of SCF ubiquitin ligase complex and microtubule associated complex. Predicted to be active in several cellular components, including cytoplasmic microtubule; kinetochore; and neuronal cell body. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 175.6), Brain (RPKM 156.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxw11 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (17737181..17834834)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (17232735..17330574)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (17542374..17640718)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 10 Neighboring gene uncharacterized LOC120095062 Neighboring gene uncharacterized LOC120095061 Neighboring gene small integral membrane protein 23 Neighboring gene uncharacterized LOC120095064 Neighboring gene uncharacterized LOC134480660

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. Bhatia N, et al. Oncogene, 2002 Feb 28. PMID 11896578
    2. The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. Ohsaki K, et al. J Biochem, 2008 Nov. PMID 18782782
    3. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Peschiaroli A, et al. Mol Cell, 2006 Aug 4. PMID 16885022
    4. Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling. Seo E, et al. Cell Signal, 2009 Jan. PMID 18929646, Free PMC Article
    5. Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Cohen S, et al. Mol Cell Biol, 2004 Jan. PMID 14673179, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/WD repeat-containing protein 11
    Names
    F-box and WD-40 domain protein 11

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395595.3 → NP_001382524.1  F-box/WD repeat-containing protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JVE0
      Conserved Domains (4) summary
      cd00200
      Location:261 → 539
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:264 → 299
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:99 → 137
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:141 → 188
      F-box-like

    2. NM_001395596.3 → NP_001382525.1  F-box/WD repeat-containing protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JVE0, A0A8I6GMC9
      Related
      ENSRNOP00000097046.1, ENSRNOT00000118897.2
      Conserved Domains (4) summary
      cd00200
      Location:206 → 484
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:209 → 244
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:44 → 82
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:86 → 133
      F-box-like

    3. NM_001414338.2 → NP_001401267.1  F-box/WD repeat-containing protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZUE3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      17737181..17834834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597240.3 → XP_017452729.1  F-box/WD repeat-containing protein 11 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JVE0
      Related
      ENSRNOP00000059948.3, ENSRNOT00000064079.4

    2. XM_017597241.3 → XP_017452730.1  F-box/WD repeat-containing protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JVE0
      Related
      ENSRNOP00000101191.1, ENSRNOT00000136657.1
      Conserved Domains (4) summary
      cd00200
      Location:227 → 505
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:230 → 265
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:65 → 103
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:107 → 154
      F-box-like

    3. XM_039085889.2 → XP_038941817.1  F-box/WD repeat-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JVE0, A0A8I6GIW9
      Related
      ENSRNOP00000091319.1, ENSRNOT00000118219.2
      Conserved Domains (4) summary
      cd00200
      Location:264 → 542
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:267 → 302
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:102 → 140
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:144 → 191
      F-box-like

    4. XM_017597238.3 → XP_017452727.1  F-box/WD repeat-containing protein 11 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVE0
      Related
      ENSRNOP00000109654.1, ENSRNOT00000170302.1

    5. XM_039085890.2 → XP_038941818.1  F-box/WD repeat-containing protein 11 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZPA1, A0A8I5ZUE3
      Related
      ENSRNOP00000079990.1, ENSRNOT00000102539.2
      Conserved Domains (4) summary
      cd00200
      Location:208 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:211 → 246
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:46 → 84
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:88 → 135
      F-box-like

    6. XM_017597243.3 → XP_017452732.1  F-box/WD repeat-containing protein 11 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JVE0, D3ZXC6
      Related
      ENSRNOP00000109220.1, ENSRNOT00000167115.1

    7. XM_017597244.3 → XP_017452733.1  F-box/WD repeat-containing protein 11 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JVE0
      Conserved Domains (4) summary
      cd00200
      Location:208 → 486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:211 → 246
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:46 → 84
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:88 → 135
      F-box-like

    8. XM_063268958.1 → XP_063125028.1  F-box/WD repeat-containing protein 11 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZUE3
      Related
      ENSRNOP00000082146.1, ENSRNOT00000098062.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106993.1: Suppressed sequence

      Description
      NM_001106993.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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