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Gdnf glial cell derived neurotrophic factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25453, updated on 9-Dec-2024

Summary

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Official Symbol: Gdnfprovided by RGD
Official Full Name: glial cell derived neurotrophic factorprovided by RGD
Primary source: RGD:2677
See related: EnsemblRapid:ENSRNOG00000083179 AllianceGenome:RGD:2677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: gndf
Summary: Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; regulation of cytokine production; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study alcohol dependence; alcohol use disorder; brain disease (multiple); and hyperprolactinemia. Biomarker of several diseases, including alcohol use disorder; irritable bowel syndrome; middle cerebral artery infarction; neuropathy (multiple); and obsessive-compulsive disorder. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; anxiety disorder; depressive disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 11.0), Liver (RPKM 10.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Gdnf in Genome Data Viewer

Location:: 2q16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (58621327..58647242)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (56894022..56919935)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (56884181..56912964)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring.
Title: The effects of induced type I diabetes on developmental regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat offspring.
Differential expression of RET and GDNF family receptor, GFR-alpha1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling.
Title: Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling.
GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRalpha1/RET/MAPK/pCREB/LOXL2 Signaling Axis.
Title: GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis.
Group II Metabotropic Glutamate Receptors Reduce Apoptosis and Regulate BDNF and GDNF Levels in Hypoxic-Ischemic Injury in Neonatal Rats.
Title: Group II Metabotropic Glutamate Receptors Reduce Apoptosis and Regulate BDNF and GDNF Levels in Hypoxic-Ischemic Injury in Neonatal Rats.
Exposure to di-(2-ethylhexyl) phthalate reduces secretion of GDNF via interfering with estrogen pathway and downregulating ERK/c-fos signaling pathway in astrocytes.
Title: Exposure to di-(2-ethylhexyl) phthalate reduces secretion of GDNF via interfering with estrogen pathway and downregulating ERK/c-fos signaling pathway in astrocytes.
GDNF requires HIF-1alpha and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge.
Title: GDNF requires HIF-1α and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge.
Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat.
Title: Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat.
MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF.
Title: MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF.
Experimental diabetes negatively affects the spermatogonial stem cells' self-renewal by suppressing GDNF network interactions.
Title: Experimental diabetes negatively affects the spermatogonial stem cells' self-renewal by suppressing GDNF network interactions.
Implantation of glial cell line-derived neurotrophic factor-expressing adipose tissue-derived stromal cells in a rat Parkinson's disease model.
Title: Implantation of glial cell line-derived neurotrophic factor-expressing adipose tissue-derived stromal cells in a rat Parkinson's disease model.

Submit: New GeneRIF Correction See all GeneRIFs (172)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gdnf (e-PCR), detects polymorphism
- UniSTS:234030

NoName (e-PCR)
- UniSTS:481584

Gdnf (e-PCR), detects polymorphism
- UniSTS:143191

Gdnf (e-PCR), detects polymorphism
- UniSTS:143192

Gdnf (e-PCR), detects polymorphism
- UniSTS:497281

GDNF_3150 (e-PCR)
- UniSTS:462211

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glial cell-derived neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables glial cell-derived neurotrophic factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in commissural neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in commissural neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in dorsal spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in dorsal spinal cord development	ISO Inferred from Sequence Orthology more info
involved_in embryonic organ development	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info
involved_in enteric nervous system development	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA stabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in midbrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in organ induction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organ induction	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peripheral nervous system development	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peristalsis	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monooxygenase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ureteric bud formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ureteric bud formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in postganglionic parasympathetic fiber development	IEA Inferred from Electronic Annotation more info
involved_in postganglionic parasympathetic fiber development	ISO Inferred from Sequence Orthology more info
involved_in postganglionic parasympathetic fiber development	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic membrane organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within postsynaptic membrane organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine uptake involved in synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine uptake involved in synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine uptake involved in synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
involved_in regulation of morphogenesis of a branching structure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of ureteric bud formation	IDA Inferred from Direct Assay more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in sympathetic nervous system development	IEA Inferred from Electronic Annotation more info
involved_in sympathetic nervous system development	ISO Inferred from Sequence Orthology more info
involved_in sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud formation	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glial cell line-derived neurotrophic factor

Names: ATF; Glial cell line derived neutrophic factor; astrocyte-derived trophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401780.1 → NP_001388709.1 glial cell line-derived neurotrophic factor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A7UGI9, A7UGJ0

Conserved Domains (1) summary

cd19380
Location:118 → 213

TGF_beta_GDNF; transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins
NM_019139.2 → NP_062012.2 glial cell line-derived neurotrophic factor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q07731, Q63214, Q64062, Q64063, Q8R485, Q9QX94, Q9QX95, Q9QXJ7, Q9QXJ8, Q9QXJ9

UniProtKB/TrEMBL

A6KGH0, A7UGJ1, F8WFL7

Related

ENSRNOP00000107775.1, ENSRNOT00000143194.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

58621327..58647242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760756.4 → XP_008758978.2 glial cell line-derived neurotrophic factor isoform X1

Conserved Domains (1) summary

cd19380
Location:220 → 315

TGF_beta_GDNF; transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins
XM_008760757.4 → XP_008758979.1 glial cell line-derived neurotrophic factor isoform X2

Conserved Domains (1) summary

pfam00019
Location:195 → 289

TGF_beta; Transforming growth factor beta like domain