Gbp5 guanylate binding protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gbp5provided by RGD
Official Full Name: guanylate binding protein 5provided by RGD
Primary source: RGD:1311040
See related: EnsemblRapid:ENSRNOG00000032240 AllianceGenome:RGD:1311040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of defense response. Predicted to act upstream of or within response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi membrane; cytoplasmic vesicle; and symbiont cell surface. Orthologous to human GBP5 (guanylate binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 138.6), Spleen (RPKM 129.5) and 9 other tissues See more
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Genomic context

Location:: 2q44

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (233910999..233930320)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (231237748..231257071)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (248178441..248196873)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis.
Title: Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cytolysis in another organism	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-18 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in symbiont cell surface	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanylate-binding protein 5

Names: guanylate nucleotide binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108569.3 → NP_001102039.2 guanylate-binding protein 5

Status: VALIDATED

Source sequence(s)

BC168951, CO559037, FM048046

UniProtKB/TrEMBL

A0A8I5ZTN7, F1M9F6

Related

ENSRNOP00000033376.4, ENSRNOT00000037339.7

Conserved Domains (3) summary

pfam02841
Location:281 → 559

GBP_C; Guanylate-binding protein, C-terminal domain

pfam02263
Location:18 → 279

GBP; Guanylate-binding protein, N-terminal domain

cd16269
Location:287 → 529

GBP_C; Guanylate-binding protein, C-terminal domain