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    Foxd3 forkhead box D3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29203, updated on 4-Jan-2025

    Summary

    Symbol
    Foxd3provided by RGD
    Full Name
    forkhead box D3provided by RGD
    Primary source
    RGD:621715
    See related
    EnsemblRapid:ENSRNOG00000066522 AllianceGenome:RGD:621715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CWH3; Hfh2; Genesis
    Summary
    Enables double-stranded DNA binding activity. Predicted to be involved in several processes, including cell differentiation; in utero embryonic development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; embryonic placenta development; and trophectodermal cell differentiation. Predicted to be located in chromatin. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Foxd3 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (119450532..119452898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (114335084..114337450)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (118346283..118349120)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NSE1 homolog, SMC5-SMC6 complex component, pseudogene 1 Neighboring gene uncharacterized LOC102556374 Neighboring gene ALG6, alpha-1,3-glucosyltransferase Neighboring gene uncharacterized LOC134479015 Neighboring gene integrin subunit beta 3 binding protein Neighboring gene EF-hand calcium binding domain 7

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis  
    involved_in cell differentiation  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor  
    acts_upstream_of_or_within embryonic placenta development  
    involved_in in utero embryonic development  
    involved_in in utero embryonic development  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within trophectodermal cell differentiation  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    located_in nucleus  

    General protein information

    Preferred Names
    forkhead box protein D3
    Names
    HFH-2
    HNF3/FH transcription factor genesis
    hepatocyte nuclear factor 3 forkhead homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080774.1NP_542952.1  forkhead box protein D3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AL61
      Related
      ENSRNOP00000089513.1, ENSRNOT00000111078.2
      Conserved Domains (1) summary
      cd20047
      Location:130226
      FH_FOXD3; Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      119450532..119452898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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