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    Mras muscle RAS oncogene homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25482, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mrasprovided by RGD
    Official Full Name
    muscle RAS oncogene homologprovided by RGD
    Primary source
    RGD:3111
    See related
    EnsemblRapid:ENSRNOG00000014060 AllianceGenome:RGD:3111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP-dependent protein binding activity; GTPase activity; and guanyl ribonucleotide binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endomembrane system and membrane. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 116.5), Brain (RPKM 96.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mras in Genome Data Viewer
    Location:
    8q31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108823374..108886104, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99944036..100006771, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107629028..107656851, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8, pseudogene 3 Neighboring gene centrosomal protein 70 Neighboring gene extended synaptotagmin 3 Neighboring gene uncharacterized LOC134480219 Neighboring gene NME/NM23 family member 9 Neighboring gene armadillo repeat containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells. Sun P, et al. Genes Cells, 2006 Sep. PMID 16923128
    2. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. Higgins EM, et al. JCI Insight, 2017 Mar 9. PMID 28289718, Free PMC Article
    3. Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology. Saito Y, et al. EMBO Rep, 2009 Jun. PMID 19444311, Free PMC Article
    4. Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton. Matsumoto K, et al. Oncogene, 1997 Nov 13. PMID 9395237
    5. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Willard FS, et al. PLoS One, 2009. PMID 19319189, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plexin-B1 is a dual functional GTPase activating protein for R-Ras and M-Ras, remodelling axon and dendrite morphology, respectively.
      Title: Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology.
    2. M-Ras is essential for neuronal differentiation in PC12 cells by inducing sustained activation of ERK pathway.
      Title: Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein M-Ras
    Names
    muscle and microspikes RAS
    ras-related protein R-Ras3
    NP_001375430.1
    NP_037113.2
    XP_038936811.1
    XP_038936812.1
    XP_038936815.1
    XP_063121019.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388501.2 → NP_001375430.1  ras-related protein M-Ras

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O09021, P97538
      UniProtKB/TrEMBL
      A0A0G2K389, A6I2D6, Q5RKJ7
      Conserved Domains (1) summary
      cd04145
      Location:12 → 176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    2. NM_012981.3 → NP_037113.2  ras-related protein M-Ras

      See identical proteins and their annotated locations for NP_037113.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O09021, P97538
      UniProtKB/TrEMBL
      A0A0G2K389, A6I2D6, Q5RKJ7
      Related
      ENSRNOP00000085134.2, ENSRNOT00000118697.2
      Conserved Domains (1) summary
      cd04145
      Location:12 → 176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      108823374..108886104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080887.1 → XP_038936815.1  ras-related protein M-Ras isoform X2

      UniProtKB/Swiss-Prot
      O09021, P97538
      UniProtKB/TrEMBL
      A0A0G2K389, A6I2D6, Q5RKJ7
      Related
      ENSRNOP00000045851.3, ENSRNOT00000050374.4
      Conserved Domains (1) summary
      cd04145
      Location:12 → 176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    2. XM_039080884.1 → XP_038936812.1  ras-related protein M-Ras isoform X2

      UniProtKB/Swiss-Prot
      O09021, P97538
      UniProtKB/TrEMBL
      A0A0G2K389, A6I2D6, Q5RKJ7
      Conserved Domains (1) summary
      cd04145
      Location:12 → 176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    3. XM_063264949.1 → XP_063121019.1  ras-related protein M-Ras isoform X2

      UniProtKB/Swiss-Prot
      O09021, P97538
      UniProtKB/TrEMBL
      A0A0G2K389, A6I2D6, Q5RKJ7

    4. XM_039080883.2 → XP_038936811.1  ras-related protein M-Ras isoform X1

      UniProtKB/TrEMBL
      A0A8I6A109, F7FMZ0
      Conserved Domains (1) summary
      cd04145
      Location:40 → 204
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97538.2 GenPept UniProtKB/Swiss-Prot:P97538

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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