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    Csnk2b casein kinase 2 beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81650, updated on 4-Jan-2025

    Summary

    Official Symbol
    Csnk2bprovided by RGD
    Official Full Name
    casein kinase 2 betaprovided by RGD
    Primary source
    RGD:619978
    See related
    EnsemblRapid:ENSRNOG00000000847 AllianceGenome:RGD:619978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ck2
    Summary
    Enables ribonucleoprotein complex binding activity. Involved in liver regeneration and response to testosterone. Located in cell projection; chromatin; and nuclear matrix. Biomarker of myocardial infarction. Orthologous to human CSNK2B (casein kinase 2 beta). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 741.5), Heart (RPKM 387.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Csnk2b in Genome Data Viewer
    Location:
    20p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3704833..3709999)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3700363..3705331)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5108692..5113675, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein M Neighboring gene G4 protein Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene lymphocyte antigen 6 family member G5C

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables chromatin binding  
    enables chromatin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables metal ion binding  
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein kinase regulator activity  
    enables protein kinase regulator activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables ribonucleoprotein complex binding PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in adiponectin-activated signaling pathway  
    involved_in adiponectin-activated signaling pathway  
    involved_in endothelial tube morphogenesis  
    involved_in endothelial tube morphogenesis  
    involved_in liver regeneration PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of viral life cycle  
    involved_in negative regulation of viral life cycle  
    involved_in peptidyl-threonine phosphorylation  
    involved_in phosphorylation  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of activin receptor signaling pathway  
    involved_in positive regulation of activin receptor signaling pathway  
    involved_in response to testosterone PubMed 
    involved_in symbiont-mediated disruption of host cell PML body  
    involved_in symbiont-mediated disruption of host cell PML body  
    Component Evidence Code Pubs
    located_in PML body  
    is_active_in PML body  
    part_of PcG protein complex  
    part_of PcG protein complex  
    part_of PcG protein complex  
    located_in cell projection PubMed 
    located_in chromatin PubMed 
    located_in chromatin  
    is_active_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nuclear matrix PubMed 
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein kinase CK2 complex  
    part_of protein kinase CK2 complex  
    part_of protein kinase CK2 complex  

    General protein information

    Preferred Names
    casein kinase II subunit beta
    Names
    CK II beta
    Csnk2b-Ly6g5b
    casein kinase 2, beta polypeptide
    casein kinase 2, beta subunit
    casein kinase II beta subunit
    phosvitin
    NP_001030315.1
    NP_112283.1
    XP_006256143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035238.2NP_001030315.1  casein kinase II subunit beta

      See identical proteins and their annotated locations for NP_001030315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC078807, BX883045
      UniProtKB/Swiss-Prot
      P67874
      UniProtKB/TrEMBL
      N0E459, Q68G11
      Related
      ENSRNOP00000098131.1, ENSRNOT00000120467.2
      Conserved Domains (1) summary
      smart01085
      Location:8191
      CK_II_beta; Casein kinase II regulatory subunit
    2. NM_031021.3NP_112283.1  casein kinase II subunit beta

      See identical proteins and their annotated locations for NP_112283.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX883045, EV778558
      UniProtKB/Swiss-Prot
      P67874
      UniProtKB/TrEMBL
      N0E459, Q68G11
      Conserved Domains (1) summary
      smart01085
      Location:8191
      CK_II_beta; Casein kinase II regulatory subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3704833..3709999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256081.4XP_006256143.1  casein kinase II subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006256143.1

      UniProtKB/TrEMBL
      A0A8L2UP98, A6KTU1
      Related
      ENSRNOP00000098132.2, ENSRNOT00000120468.2
      Conserved Domains (1) summary
      smart01085
      Location:28211
      CK_II_beta; Casein kinase II regulatory subunit
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