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    Srpk3 SRSF protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293854, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Srpk3provided by RGD
    Official Full Name
    SRSF protein kinase 3provided by RGD
    Primary source
    RGD:727856
    See related
    EnsemblRapid:ENSRNOG00000054548 AllianceGenome:RGD:727856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mssk1; Stk23
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle tissue development; regulation of mRNA processing; and spliceosomal complex assembly. Predicted to act upstream of or within protein phosphorylation and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Orthologous to human SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 239.6), Heart (RPKM 179.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srpk3 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156661888..156666537)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151510452..151515208)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157008773..157014342, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene plexin B3 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene signal sequence receptor subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Nakagawa O, et al. Genes Dev, 2005 Sep 1. PMID 16140986, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SRSF protein kinase 3
    Names
    SFRS protein kinase 3
    muscle-specific serine kinase 1
    muscle-specific serine kinase 1; MSSK1
    serine arginine rich protein-specific kinase 3
    serine/threonine kinase 23
    serine/threonine-protein kinase SRPK3
    XP_006229620.1
    XP_006229621.1
    XP_006229622.1
    XP_006229623.1
    XP_008771839.1
    XP_008771840.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433945.1 → NP_001420874.1  SRSF protein kinase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KRV7, G3V8I2, Q6V9W0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156661888..156666537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229558.5 → XP_006229620.1  SRSF protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAH6
      Conserved Domains (2) summary
      smart00220
      Location:102 → 591
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:91 → 591
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006229559.5 → XP_006229621.1  SRSF protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAH6
      Related
      ENSRNOP00000075400.2, ENSRNOT00000082711.3
      Conserved Domains (2) summary
      smart00220
      Location:102 → 590
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:91 → 590
      PKc_like; Protein Kinases, catalytic domain

    3. XM_008773617.4 → XP_008771839.1  SRSF protein kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2KAH6
      Conserved Domains (2) summary
      smart00220
      Location:102 → 526
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:91 → 526
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006229560.5 → XP_006229622.1  SRSF protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAH6
      Conserved Domains (2) summary
      smart00220
      Location:102 → 589
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14218
      Location:91 → 589
      STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

    5. XM_006229561.5 → XP_006229623.1  SRSF protein kinase 3 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:102 → 588
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14218
      Location:91 → 588
      STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

    6. XM_008773618.4 → XP_008771840.1  SRSF protein kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2KAH6
      Conserved Domains (2) summary
      smart00220
      Location:102 → 524
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:91 → 524
      PKc_like; Protein Kinases, catalytic domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_184045.2: Suppressed sequence

      Description
      NM_184045.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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