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    Sypl1 synaptophysin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sypl1provided by RGD
    Official Full Name
    synaptophysin-like 1provided by RGD
    Primary source
    RGD:1359569
    See related
    EnsemblRapid:ENSRNOG00000009856 AllianceGenome:RGD:1359569
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sypl
    Summary
    Is active in synaptic vesicle membrane. Orthologous to human SYPL1 (synaptophysin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 495.4), Kidney (RPKM 473.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sypl1 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (55292555..55311519)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (49565111..49585205)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (52265920..52286037)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 69, pseudogene 1 Neighboring gene HEXIM P-TEFb complex subunit 2, pseudogene 1 Neighboring gene uncharacterized LOC102547473 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene cadherin-related family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. Haass NK, et al. J Cell Biol, 1996 Aug. PMID 8707851, Free PMC Article
    2. Molecular anatomy of a trafficking organelle. Takamori S, et al. Cell, 2006 Nov 17. PMID 17110340
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptophysin-like protein 1
    Names
    Pan I
    pantophysin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014263.1 → NP_001014285.1  synaptophysin-like protein 1

      See identical proteins and their annotated locations for NP_001014285.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082078
      UniProtKB/TrEMBL
      A0A9K3Y7R4, A6HB73, D3ZZU5, Q66H18
      Related
      ENSRNOP00000088430.2, ENSRNOT00000108721.2
      Conserved Domains (1) summary
      pfam01284
      Location:109 → 230
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      55292555..55311519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112628.2 → XP_038968556.1  synaptophysin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6HB74
      Conserved Domains (1) summary
      pfam01284
      Location:109 → 186
      MARVEL; Membrane-associating domain
    Nucleotide Protein Strain
    Heading Accession and Version

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