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    Tmem250 transmembrane protein 250 [ Mus musculus (house mouse) ]

    Gene ID: 109299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem250provided by MGI
    Official Full Name
    transmembrane protein 250provided by MGI
    Primary source
    MGI:MGI:1924939
    See related
    Ensembl:ENSMUSG00000087679 AllianceGenome:MGI:1924939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem250-ps; C330006A16Rik
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in several processes, including cilium assembly; cytoskeleton-dependent cytokinesis; and positive regulation of viral process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Orthologous to human TMEM250 (transmembrane protein 250). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 143.7), ovary adult (RPKM 80.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem250 in Genome Data Viewer
    Location:
    2 A3; 2 18.35 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26026819..26030518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26136807..26140506, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03972 Neighboring gene nucleus accumbens associated 2, BEN and BTB (POZ) domain containing Neighboring gene STARR-seq mESC enhancer starr_03973 Neighboring gene VISTA enhancer mm561 Neighboring gene predicted gene, 54107 Neighboring gene STARR-seq mESC enhancer starr_03976 Neighboring gene predicted gene, 35745 Neighboring gene LIM homeobox protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 250
    Names
    transmembrane protein 250, pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256521.1 → NP_001243450.1  transmembrane protein 250

      See identical proteins and their annotated locations for NP_001243450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL845455, DN176963
      Consensus CDS
      CCDS89452.1
      UniProtKB/TrEMBL
      A0A571BES4
      Related
      ENSMUSP00000158596.2, ENSMUST00000133808.2
      Conserved Domains (1) summary
      pfam17685
      Location:1 → 139
      DUF5533; Family of unknown function (DUF5533)

    2. NM_001256522.1 → NP_001243451.1  transmembrane protein 250

      See identical proteins and their annotated locations for NP_001243451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL845455
      Consensus CDS
      CCDS89452.1
      UniProtKB/TrEMBL
      A0A571BES4
      Related
      ENSMUSP00000158791.2, ENSMUST00000163836.2
      Conserved Domains (1) summary
      pfam17685
      Location:1 → 139
      DUF5533; Family of unknown function (DUF5533)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26026819..26030518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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