Snx1 sorting nexin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx1provided by MGI
Official Full Name: sorting nexin 1provided by MGI
Primary source: MGI:MGI:1928395
See related: Ensembl:ENSMUSG00000032382 AllianceGenome:MGI:1928395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in neuron projection development. Acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. Located in several cellular components, including dendritic spine; early endosome; and postsynaptic density. Is active in postsynaptic density, intracellular component. Is extrinsic component of postsynaptic endosome membrane. Is expressed in several structures, including egg cylinder and small intestine. Orthologous to human SNX1 (sorting nexin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 53.7), genital fat pad adult (RPKM 44.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 35.71 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (65995409..66032168, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (66088127..66124886, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural insights into membrane remodeling by SNX1.
Title: Structural insights into membrane remodeling by SNX1.
Data suggest that both, N-terminal and C-terminal region of SNX1 play critical role in the normal trafficking of the group I metabotropic glutamate receptors (mGlur1). In addition, study shows that SNX1 regulates the trafficking of mGluR1 through the interaction with hepatocyte growth factor-regulated tyrosine kinase substrate.
Title: A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors.
SNX1 interacts with Arf6 to mediate neurite formation which is regulated by EFA6A.
Title: EFA6A, a guanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth.
SNX1 has a crucial role in D(5)R trafficking and SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension
Title: Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.
A RUN Domain from DENND5/Rab6IP1 binds sorting Nexin 1 and is involved in the trafficking of vesicles at the level of Golgi.
Title: Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1.
show that mice lacking sorting nexin 1 or sorting nexin 2 are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation.
Title: Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice.
HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains
Title: A novel hook-related protein family and the characterization of hook-related protein 1.
Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1), and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 in retromer activity during embryonic development.
Title: Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:236171 (e-PCR)
- UniSTS:236171

UniSTS:478959 (e-PCR)
- UniSTS:478959

Snx1 (e-PCR), detects polymorphism
- UniSTS:478959

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables leptin receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in early endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extrinsic component of postsynaptic endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IEP Inferred from Expression Pattern more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info
part_of retromer, tubulation complex	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019727.2 → NP_062701.2 sorting nexin-1

See identical proteins and their annotated locations for NP_062701.2

Status: VALIDATED

Source sequence(s)

AB019214, AF154120, BB198783, BC066189

Consensus CDS

CCDS52839.1

UniProtKB/TrEMBL

Q3U4S1, Q6NZD2

Related

ENSMUSP00000034946.9, ENSMUST00000034946.15

Conserved Domains (4) summary

cd07281
Location:144 → 267

PX_SNX1; The phosphoinositide binding Phox Homology domain of Sorting Nexin 1

cd07665
Location:285 → 518

BAR_SNX1; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 1

COG5391
Location:17 → 511

COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]

pfam03700
Location:53 → 129

Sorting_nexin; Sorting nexin, N-terminal domain