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    MMH-1 MUTM homolog-1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841681, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MMH-1
    Official Full Name
    MUTM homolog-1
    Primary source
    TAIR:AT1G52500
    Locus tag
    AT1G52500
    See related
    Araport:AT1G52500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 1; ATFPG-1; ATFPG-2; ATMMH-1; ATMMH-2; F6D8.37; F6D8_37; FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 1; FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 2; FPG-1; FPG-2; MMH; MMH-2; MUTM homolog; MUTM homolog-1
    Summary
    Encodes one of the splice variants of Arabidopsis thaliana MutM homolog. Encodes a formamidopyrimidine-DNA glycosylase that has abasic lyase activity and is able to nick double- stranded oligonucleotides containing 8-oxo-7,8-dihydroguanine (8-oxoG) in vitro.
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    Genomic context

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    See MMH-1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (19559880..19563113)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box/associated interaction domain protein Neighboring gene F-box/associated interaction domain protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene FAR1-related sequence 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. Duclos S, et al. DNA Repair (Amst), 2012 Sep 1. PMID 22789755, Free PMC Article
    2. Alternative forms of formamidopyrimidine-DNA glycosylase from Arabidopsis thaliana. Gao MJ, et al. Photochem Photobiol, 2001 Feb. PMID 11272725
    3. Molecular cloning of AtMMH, an Arabidopsis thaliana ortholog of the Escherichia coli mutM gene, and analysis of functional domains of its product. Ohtsubo T, et al. Mol Gen Genet, 1998 Oct. PMID 9819050
    4. Arabidopsis ZDP DNA 3'-phosphatase and ARP endonuclease function in 8-oxoG repair initiated by FPG and OGG1 DNA glycosylases. Córdoba-Cañero D, et al. Plant J, 2014 Sep. PMID 24934622
    5. The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates. Li J, et al. Plant Cell, 2022 Feb 3. PMID 34791445, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
      Title: The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
    2. Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP in downstream steps.
      Title: Arabidopsis ZDP DNA 3'-phosphatase and ARP endonuclease function in 8-oxoG repair initiated by FPG and OGG1 DNA glycosylases.
    3. The most striking difference between AthFpg and the bacterial Fpg proteins is the absence of the alphaF-beta9/10 loop, previously shown to be required for 8-oxoG recognition.
      Title: Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001333547.1
    NM_001333548.1
    NM_001333549.1
    NM_104128.3
    NM_179467.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA N-glycosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidized purine nucleobase lesion DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MUTM homolog-1
    NP_564608.1
    • MUTM homolog-1 (MMH-1); CONTAINS InterPro DOMAIN/s: Ribosomal protein S13-like, H2TH (InterPro:IPR010979), DNA glycosylase/AP lyase, H2TH DNA-binding (InterPro:IPR015886), DNA glycosylase/AP lyase, catalytic domain (InterPro:IPR012319), DNA glycosylase/AP lyase (InterPro:IPR000191); Has 11102 Blast hits to 10156 proteins in 2240 species: Archae - 10; Bacteria - 5065; Metazoa - 1812; Fungi - 570; Plants - 321; Viruses - 42; Other Eukaryotes - 3282 (source: NCBI BLink).
    NP_849798.1
    • MMH-2; CONTAINS InterPro DOMAIN/s: Ribosomal protein S13-like, H2TH (InterPro:IPR010979), DNA glycosylase/AP lyase, H2TH DNA-binding (InterPro:IPR015886), DNA glycosylase/AP lyase, catalytic domain (InterPro:IPR012319), DNA glycosylase/AP lyase (InterPro:IPR000191); Has 7507 Blast hits to 7502 proteins in 2073 species: Archae - 6; Bacteria - 4936; Metazoa - 104; Fungi - 102; Plants - 73; Viruses - 8; Other Eukaryotes - 2278 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19559880..19563113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104128.3 → NP_564608.1  MUTM homolog-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80358, O80359, Q9SBB4
      UniProtKB/TrEMBL
      A0A654ETJ5
      Conserved Domains (1) summary
      TIGR00577
      Location:2 → 276
      fpg; DNA-formamidopyrimidine glycosylase

    2. NM_001333547.1 → NP_001322993.1  MUTM homolog-1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80358
      Conserved Domains (1) summary
      TIGR00577
      Location:2 → 256
      fpg; DNA-formamidopyrimidine glycosylase

    3. NM_001333548.1 → NP_001322994.1  MUTM homolog-1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AVR7

    4. NM_001333549.1 → NP_001322995.1  MUTM homolog-1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VZV9, A0A178W0P8, A0A1P8AVL9, A0A384LQJ0

    5. NM_179467.3 → NP_849798.1  MUTM homolog-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849798.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80358
      Conserved Domains (1) summary
      TIGR00577
      Location:2 → 256
      fpg; DNA-formamidopyrimidine glycosylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80358.1

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