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    SPA3 SPA1-related 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820767, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPA3
    Official Full Name
    SPA1-related 3
    Primary source
    TAIR:AT3G15354
    Locus tag
    AT3G15354
    See related
    Araport:AT3G15354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    SPA1-related 3
    Summary
    Encodes a member of the SPA (suppressor of phyA-105) protein family (SPA1-SPA4). SPA proteins contain an N-terminal serine/threonine kinase-like motif followed by a coiled-coil structure and a C-terminal WD-repeat domain. SPA proteins function redundantly in suppressing photomorphogenesis in dark- and light-grown seedlings. SPA3 (and SPA4) predominantly regulates elongation growth in adult plants.
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    Genomic context

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    See SPA3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (5169095..5173105, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene proton pump interactor 2 Neighboring gene Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein Neighboring gene uncharacterized protein Neighboring gene Legume lectin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SPA1-like proteins SPA3 and SPA4 repress photomorphogenesis in the light. Laubinger S, et al. Plant J, 2003 Aug. PMID 12887588
    2. SPA Proteins Affect the Subcellular Localization of COP1 in the COP1/SPA Ubiquitin Ligase Complex during Photomorphogenesis. Balcerowicz M, et al. Plant Physiol, 2017 Jul. PMID 28536102, Free PMC Article
    3. Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B. Huang X, et al. Proc Natl Acad Sci U S A, 2013 Oct 8. PMID 24067658, Free PMC Article
    4. Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio. Rolauffs S, et al. Plant Physiol, 2012 Dec. PMID 23093358, Free PMC Article
    5. Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development. Zhu D, et al. Plant Cell, 2008 Sep. PMID 18812498, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPA proteins have a dual role: (1) they are required for light-responsiveness of COP1 subcellular localization, and (2) they promote COP1 activity in darkness in a fashion that is independent of the nuclear import/nuclear retention of COP1.
      Title: SPA Proteins Affect the Subcellular Localization of COP1 in the COP1/SPA Ubiquitin Ligase Complex during Photomorphogenesis.
    2. COP1/SPA activity, via LONG HYPOCOTYL IN FR LIGHT1, is required for shade-induced modulation of the auxin biosynthesis pathway and thereby enhances cell elongation in low red:far red.
      Title: Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio.
    3. SPA3 protein can self-associate or interact with each other, forming stable heterogeneous group of SPA-COP1 complexes regardless of light conditions but exhibit distinct expression profiles in different tissues and light conditions.
      Title: Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338163.1
    NM_001338164.1
    NM_148725.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in photomorphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SPA1-related 3
    NP_683567.1
    • SPA1-related 3 (SPA3); FUNCTIONS IN: protein binding, signal transducer activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), Serine/threonine-protein kinase domain (InterPro:IPR002290), WD40 repeat (InterPro:IPR001680), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), WD40 repeat-like-containing domain (InterPro:IPR011046), Protein kinase, catalytic domain (InterPro:IPR000719), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: SPA1-related 4 (TAIR:AT1G53090.2); Has 21839 Blast hits to 15304 proteins in 547 species: Archae - 20; Bacteria - 4030; Metazoa - 7396; Fungi - 4798; Plants - 2703; Viruses - 2; Other Eukaryotes - 2890 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5169095..5173105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338162.1 → NP_001327624.1  SPA1-related 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IYP4, F4ZN82, F4ZN83, Q9LJR3
      UniProtKB/TrEMBL
      A0A654F925, A0A7G2EMT8
      Conserved Domains (2) summary
      PLN00181
      Location:1 → 844
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:537 → 582
      7WD40; WD40 repeat [structural motif]

    2. NM_001338161.1 → NP_001327623.1  SPA1-related 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VH25, A0A178VHE8

    3. NM_148725.4 → NP_683567.1  SPA1-related 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_683567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F925
      Conserved Domains (4) summary
      PLN00181
      Location:1 → 836
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:537 → 582
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:537 → 832
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl21453
      Location:75 → 295
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001338163.1 → NP_001327621.1  SPA1-related 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LSW4
      Conserved Domains (2) summary
      PLN00181
      Location:1 → 594
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:287 → 332
      7WD40; WD40 repeat [structural motif]

    5. NM_001338164.1 → NP_001327622.1  SPA1-related 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LSW4
      Conserved Domains (2) summary
      PLN00181
      Location:1 → 594
      PLN00181; protein SPA1-RELATED; Provisional
      sd00039
      Location:287 → 332
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LJR3.1

    Gene LinkOut

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